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High resolution multicolor-banding: a new technique for refined FISH analysis of human chromosomes
A new multicolor-banding technique has been developed which allows the differentiation of chromosome region specific areas at the band level. This technique is based on the use of differently labeledExpand
Homologous sequences at human chromosome 9 bands p12 and q13-21.1 are involved in different patterns of pericentric rearrangements
It is demonstrated that constitutional inversions affecting the pericentromeric region of chromosome 9 carry breakpoints located preferentially in 9p12 or 9q13-21.1 and less frequently in 9q12.1, two regions that are usually not distinguishable by molecular cytogenetic techniques. Expand
Cloning of TRAP, a ligand for CD40 on human T cells
A cDNA clone, designated TRAP (TNF‐related activation protein), isolated from a collection of T cell activation genes, is highly similar to an identified murine CD40 ligand both at the cDNA and the protein levels, and related to tumor necrosis factor/lymphotoxin. Expand
Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins
It is suggested that the subtle phenotype of LMP-deficient cell lines results from the compensatory expression in these lines of two other proteasome subunits, MB1 and Delta. Expand
Genomic organization of the human folate receptor genes on chromosome 11q13.
The organization of all the human FOLR-related genes was determined by PFGE of YAC DNA and by YAC fragmentation, and a physical map of over 900 kb of the surrounding region was constructed. Expand
A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1.
Extensive SSCP and sequence analysis of over 100 tumour and normal DNAs from familial and sporadic breast cancers and sporadic ovarian cancers failed to detect mutations in the coding region of this gene. Expand
The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary
The hybridization of the 2q microlibrary to chromosomes of Old World monkeys gave a different pattern from that in the gorilla and the orang-utan, but a pattern similar to that of chimpanzees, which suggests convergence of chromosomal rearrangements in different phylogenetic lines. Expand
Cloning defined regions of the human genome by microdissection of banded chromosomes and enzymatic amplification
The dissection of the Langer-Giedion syndrome region on chromosome 8 from GTG-banded metaphase chromosomes and the universal enzymatic amplification of the dissected DNA is described, demonstrating that thousands of region-specific probes can be isolated within ten days. Expand
Cloning of ATAC, an activation‐induced, chemokine‐related molecule exclusively expressed in CD8+ T lymphocytes
Analysis of tissue distribution determined that ATAC mRNA of approxiamtely 0.9 kb is exclusively expressed in activated CD8+ T cells, and structural features predict the cleavage and secretion of a mature ATAC protein of approximately 10 kDa from the 12.52‐kDa precursor. Expand
Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily.
A complementary DNA is isolated for B-CAM which encodes a 588-amino acid protein which is a novel member of the immunoglobulin superfamily with a characteristic V-V-C-C2-C3-C4-C1-C5 domain structure, suggestive of a role for B -CAM in cell-cell or cell-matrix adhesion. Expand