• Publications
  • Influence
Report of the expert committee on the diagnosis and classification of diabetes mellitus.
TLDR
It was deemed essential to develop an appropriate, uniform terminology and a functional, working classification of diabetes that reflects the current knowledge about the disease. Expand
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
TLDR
It is concluded that IL-22 and IL-17F are key natural defenders against CMC and that the immunodeficiency underlying CMC in both patient groups has an autoimmune basis. Expand
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
TLDR
A striking sequence similarity between the two GADs and Coxsackievirus, a virus that has been associated with IDDM both in humans and in experimental animals, suggests that molecular mimicry may play a role in the pathogenesis of IDDM. Expand
Two Types of Autoimmune Addison's Disease Associated with Different Polyglandular Autoimmune (PGA) Syndromes
TLDR
Evidence is provided to support the concept that the Addison's diseases in Type I and II PGA syndromes have different genetic bases, as related to HLA haplotypes, and possibly have different underlying pathogeneses. Expand
The pathogenesis of insulin-dependent diabetes mellitus.
TLDR
Much has been learned during the past decade about the underlying genetics, natural history, and pathogenesis of IDDM, and some of this new information is described to be used to prevent the disease. Expand
Multiple immuno-regulatory defects in type-1 diabetes.
TLDR
It is suggested that multiple immunoregulatory T (Treg) cell defects underlie islet cell autoimmunity leading to IMD in humans and that these lesions may be part of a broad T cell defect. Expand
Insulin resistance syndrome in children.
TLDR
The looming tragedy from growing numbers of individuals affected by obesity/insulin resistance syndrome requires urgent public health approaches directed at their early identification and intervention during childhood, including educating the public on the topic, limiting the consumption of sucrose-containing drinks and foods with high carbohydrate and fat contents, and promoting exercise programs in the authors' nation's homes and schools. Expand
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
TLDR
It is concluded that IA-2 is a major islet cell autoantigen in IDDM, and, together with GAD65, is responsible for much of the reactivity of ICA with pancreatic islets. Expand
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.
TLDR
Cellular immunological findings support the epidemiological evidence suggesting an inductive role for enteroviruses like Coxsackie B in the autoimmunity underlying IDD. Expand
Maturity-onset diabetes of youth in black Americans.
TLDR
The atypical form of diabetes in black Americans can be distinguished from classically defined insulin-dependent diabetes and may be best classified as a form of maturity-onset diabetes of youth. Expand
...
1
2
3
4
5
...