• Publications
  • Influence
Elephant shark genome provides unique insights into gnathostome evolution
The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins andExpand
  • 491
  • 34
  • PDF
Origin and evolution of the adaptive immune system: genetic events and selective pressures
The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing antigen receptors that are generated by somatic recombination, arose approximately 500 million years ago in jawedExpand
  • 596
  • 31
  • PDF
The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, weExpand
  • 453
  • 19
  • PDF
The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28
Summary: Production of antigenic peptides that serve as MHC class I ligands is essential for initiation of cell‐mediated immunity. Accumulating evidence indicates that the proteasome, a largeExpand
  • 292
  • 18
Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: “waiting for Godot”
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune-related genes in an organism that occupies a key phylogenetic positionExpand
  • 272
  • 18
  • PDF
A Novel Type of E3 Ligase for the Ufm1 Conjugation System*
The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is known to covalentlyExpand
  • 115
  • 18
Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system.
MHC gene organization (size, complexity, gene order) differs markedly among different species, and yet all nonmammalian vertebrates examined to date have a true "class I region" with tight linkage ofExpand
  • 344
  • 17
Cardiac fibrosis in mice lacking brain natriuretic peptide.
Cardiac fibrosis, defined as a proliferation of interstitial fibroblasts and biosynthesis of extracellular matrix components in the ventricles of the heart, is a consequence of remodeling processesExpand
  • 550
  • 13
  • PDF
The 2R hypothesis: an update.
  • M. Kasahara
  • Biology, Medicine
  • Current opinion in immunology
  • 1 October 2007
Nearly forty years ago, Susumu Ohno proposed that one or two rounds of whole genome duplication took place close to the origin of vertebrates. The refined version of this proposal, known as the twoExpand
  • 235
  • 11
Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.
The 20S proteasome is a catalytic core of the 26S proteasome, a central enzyme in the degradation of ubiquitin-conjugated proteins. It is composed of 14 distinct gene products that form four stackedExpand
  • 117
  • 9