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Elephant shark genome provides unique insights into gnathostome evolution
The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins and… Expand
Origin and evolution of the adaptive immune system: genetic events and selective pressures
The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing antigen receptors that are generated by somatic recombination, arose approximately 500 million years ago in jawed… Expand
The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we… Expand
The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28
Summary: Production of antigenic peptides that serve as MHC class I ligands is essential for initiation of cell‐mediated immunity. Accumulating evidence indicates that the proteasome, a large… Expand
Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: “waiting for Godot”
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune-related genes in an organism that occupies a key phylogenetic position… Expand
A Novel Type of E3 Ligase for the Ufm1 Conjugation System*
- Kanako Tatsumi, Y. Sou, +10 authors M. Komatsu
- Biology, Medicine
- The Journal of Biological Chemistry
- 14 December 2009
The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is known to covalently… Expand
Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system.
MHC gene organization (size, complexity, gene order) differs markedly among different species, and yet all nonmammalian vertebrates examined to date have a true "class I region" with tight linkage of… Expand
Cardiac fibrosis in mice lacking brain natriuretic peptide.
- N. Tamura, Y. Ogawa, +12 authors M. Katsuki
- Proceedings of the National Academy of Sciences…
- 11 April 2000
Cardiac fibrosis, defined as a proliferation of interstitial fibroblasts and biosynthesis of extracellular matrix components in the ventricles of the heart, is a consequence of remodeling processes… Expand
The 2R hypothesis: an update.
- M. Kasahara
- Biology, Medicine
- Current opinion in immunology
- 1 October 2007
Nearly forty years ago, Susumu Ohno proposed that one or two rounds of whole genome duplication took place close to the origin of vertebrates. The refined version of this proposal, known as the two… Expand
Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.
The 20S proteasome is a catalytic core of the 26S proteasome, a central enzyme in the degradation of ubiquitin-conjugated proteins. It is composed of 14 distinct gene products that form four stacked… Expand