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Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection. Expand
Gene map of the extended human MHC
A gene map of the xMHC is presented and its content in relation to paralogy, polymorphism, immune function and disease is reviewed. Expand
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
The analysis provides informative tag SNPs that capture much of the common variation in the MHC region and that could be used in disease association studies, and it provides new insight into the evolutionary dynamics and ancestral origins of the HLA loci and their haplotypes. Expand
Plasticity in the organization and sequences of human KIR/ILT gene families.
- M. Wilson, M. Torkar, +5 authors J. Trowsdale
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 25 April 2000
Analysis of Alu repeats and comparison of KIR gene sequences are consistent with a recent origin, and KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands. Expand
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
- S. Hiby, James J. Walker, +4 authors A. Moffett
- Biology, Medicine
- The Journal of experimental medicine
- 18 October 2004
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an… Expand
Genetic Control of MHC Class II Expression
The transcriptosome complex formed at class II promoters is a model for induction of gene expression and a master controller that orchestrates expression but does not bind directly to the promoter. Expand
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei.
Transcriptional up-regulation of genes in the major histocompatibility complex by interferon-gamma led to an increase in the frequency with which this large gene cluster was found on an external chromatin loop, consistent with an association between large-scale chromatin organization of specific genomic regions and their transcriptional status. Expand
A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene, a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Expand
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
The results provide new insight into the diversity of KIR repertoire and its adaptation to virus infection, suggesting a role for both activating and inhibitory KIRs in immunity to CMV infection. Expand
Comparative genomics of major histocompatibility complexes
This review compares maps of MHC gene orders in commonly studied species, where extensive sequencing has been performed, and suggests rapid evolution of M HC genes after divergence from a common ancestor. Expand