Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
- Maureen P. Martin, Xiaojiang Gao, M. Carrington
- BiologyNature Genetics
- 1 August 2002
The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection.
Gene map of the extended human MHC
- R. Horton, L. Wilming, S. Beck
- BiologyNature reviews genetics
- 1 December 2004
A gene map of the xMHC is presented and its content in relation to paralogy, polymorphism, immune function and disease is reviewed.
Plasticity in the organization and sequences of human KIR/ILT gene families.
- M. Wilson, M. Torkar, J. Trowsdale
- BiologyProceedings of the National Academy of Sciences…
- 25 April 2000
Analysis of Alu repeats and comparison of KIR gene sequences are consistent with a recent origin, and KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands.
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
- P. D. Bakker, G. McVean, J. Rioux
- BiologyNature Genetics
- 24 September 2006
The analysis provides informative tag SNPs that capture much of the common variation in the MHC region and that could be used in disease association studies, and it provides new insight into the evolutionary dynamics and ancestral origins of the HLA loci and their haplotypes.
Genetic Control of MHC Class II Expression
- J. Ting, J. Trowsdale
- BiologyCell
- 19 April 2002
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
- S. Hiby, James J. Walker, A. Moffett
- BiologyJournal of Experimental Medicine
- 18 October 2004
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an…
A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
- B. Ortmann, J. Copeman, P. Cresswell
- BiologyScience
- 29 August 1997
The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene, a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal.
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
- V. Béziat, Lisa L. Liu, K. Malmberg
- BiologyBlood
- 4 April 2013
The results provide new insight into the diversity of KIR repertoire and its adaptation to virus infection, suggesting a role for both activating and inhibitory KIRs in immunity to CMV infection.
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei.
- E. Volpi, E. Chevret, D. Sheer
- BiologyJournal of Cell Science
- 1 May 2000
Transcriptional up-regulation of genes in the major histocompatibility complex by interferon-gamma led to an increase in the frequency with which this large gene cluster was found on an external chromatin loop, consistent with an association between large-scale chromatin organization of specific genomic regions and their transcriptional status.
Constitutive and induced expression of DC‐SIGN on dendritic cell and macrophage subpopulations in situ and in vitro
- E. Soilleux, L. Morris, Benhur Lee
- BiologyJournal of Leukocyte Biology
- 1 March 2002
The data demonstrate the relevant populations of DC andmacrophages that express DC‐SIGN in vivo where it may impact theefficiency of virus infection and indicate thatDC‐SIGN expression maybe involved in the Th2 axis of immunity.
...
...