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Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to… Expand The effects of the active ingredient of Cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), and of the highly addictive drug… Expand THE ORL1 receptor, an orphan receptor whose human1and murine2á¤-8 complementary DNAs have recently been characterized… Expand The cloning of the opioid receptors has profoundly affected our understanding of opioid-receptor expression, regulation and… Expand Selective PCR amplification of human and mouse genomic DNAs with oligonucleotides encoding highly conserved regions of the… Expand Abstract
A random primed expression cDNA library was constructed from the RNA of NG 108-15 cells. Pools of plasmid DNA were… Expand Opiate drugs have potent analgesic and addictive properties. These drugs interact with receptors that also mediate the response… Expand Abstract There is a wide body of evidence to suggest the existence of at least three distinct opioid receptor types in the CNS… Expand In the guinea pig ileum myenteric plexus--longitudinal muscle preparation, dynorphin-(1--13) and the prototypical kappa agonist… Expand Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe… Expand