Intraocular pressure response to loteprednol etabonate in known steroid responders.
LE has less effect on IOP when compared to the IOP response induced by PA, and LE may become a clinically useful ocular steroid with a favorable IOP-safety profile.
Nalmefene: Safety and Kinetics After Single and Multiple Oral Doses of a New Opioid Antagonist
Both studies indicate that orally administered nalmefene has a wide margin of safety in healthy men and exhibits a linear pharmacokinetic profile at the doses tested.
The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.
- W. Dewey, L. Harris, J. Howes, J. A. Nuite
- BiologyJournal of Pharmacology and Experimental…
- 1 November 1970
Investigation of the effect of a number of agents which alter central neurohumeral tone on the activity of morphine and the narcotic antagonists in the tail-flick and the phenylquinone tests indicates a possible involvement of central serotonergic mechanisms.
Narcotic-antagonist analgesics: interactions with cholinergic systems.
- L. Harris, W. Dewey, J. Howes, J. Kennedy, H. Pars
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 September 1969
A high correlation has been found between the activity of these compounds in this test procedure and their potency as analgesics in man and the hypothesis that cholinergic systems may be involved in the analgesic action of these drugs.
A randomized, double-masked, placebo-controlled parallel study of 0.2% loteprednol etabonate in patients with seasonal allergic conjunctivitis.
Pharmacology of some Marijuana Constituents and Two Heterocyclic Analogues
Some preliminary pharmacological results with pure synthetic Δ8 and Δ9-tetrahydrocannabinol (Δ9-THC) are reported, and the effect of the insertion of a heterocyclic atom in ring C on the pharmacology of these agents are described.
A randomized, double-masked, placebo-controlled parallel study of loteprednol etabonate 0.2% in patients with seasonal allergic conjunctivitis.
The effect of narcotics and narcotic antagonists on the tail‐flick response in spinal mice
- W. Dewey, J. Synder, L. Harris, J. Howes
- BiologyThe Journal of pharmacy and pharmacology
- 1 August 1969
The tail-flick test in mice is used to elucidate the mechanism of action of morphine and the narcotic-antagonist analgesics and an increase in central adrenergic or 5-hydroxytryptamine tone will increase the activity of morphine in intact mice in the tail- Flick test.
A controlled evaluation of the efficacy and safety of loteprednol etabonate in the prophylactic treatment of seasonal allergic conjunctivitis. Loteprednol Allergic Conjunctivitis Study Group.
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary…
The rapid therapeutic response combined with the low incidence and transient nature of any intraocular pressure increase suggests that loteprednol is an appropriate treatment for giant papillary conjunctivitis.