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Noradrenergic mechanisms in neurodegenerative diseases: a theory
Evidence is given here to evidence that several neurodegenerative diseases and syndromes share common elements, including profound LC cell loss, and may in fact be different manifestations of a common pathophysiological process. Expand
Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus
Six pairs of female squirrel monkeys were given a daily intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 9-14 days, beginning the same day on which they receivedExpand
Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat
It is suggested that alpha-adrenergic mechanisms and, in particular, alpha 2- adrenoceptors, may be involved in reserpine-induced tremor and rigidity in parkinsonian motor signs. Expand
Opiate States of Memory: Receptor Mechanisms
It appears that a particular magnitude of μ opiate receptor activation produces a state to which a memory trace can be confined in a highly selective manner. Expand
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
The effects on apomorphine-induced circling indicate an influence of alpha-2 adrenoceptor compounds on nigrostriatal neurotransmission at sites downstream from the dopaminergic neurons themselves. Expand
Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments
It is suggested that stimulus generalization with cocaine may be contingent upon increasing the functional availability of endogenous dopamine and, perhaps, of norepinephrine irrespective of the presynaptic mechanism from which such increase may result and that differential stimulus generalized of drugs with cocaine (in terms of dose, subjects, slope, and rate effects) may parallel their differential primary reinforcing properties. Expand
Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT1A receptor agonist
The signal transduction profile of F15599, a novel 5‐HT1A receptor agonist, is described, which suggests activation of post‐synaptic 5‐ HT1A receptors may provide enhanced therapy against depression. Expand
The Alpha2-Adrenoceptor Antagonist Dexefaroxan Enhances Hippocampal Neurogenesis by Increasing the Survival and Differentiation of New Granule Cells
By promoting the survival of new endogenously formed neurons, dexefaroxan treatment represents a potential therapeutic strategy for maintaining adult neurogenesis in neurodegenerative conditions, such as Alzheimer's disease, that affect the hippocampus. Expand
Noradrenaline depletion exacerbates MPTP-induced striatal dopamine loss in mice.
Results support the hypothesis that damage to the locus coeruleus-noradrenergic system, by removing a facilitatory influence on the nigrostriatal dopamine system, interferes with the ability of the nig Frostriatal pathway to compensate for or recover from injury. Expand
NMDA antagonists make learning and recall state-dependent.
The data do not support the widely held notion that NMDA antagonists produce deficits in memory or retention; instead, at doses considerably lower than those impairing acquisition, NMda antagonists produce a state upon which the recall of the newly learned response is dependent. Expand