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Noradrenergic mechanisms in neurodegenerative diseases: a theory

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Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus…

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Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat

  • F. Colpaert
  • Biology, Psychology
    Neuropharmacology
  • 1 September 1987
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Opiate States of Memory: Receptor Mechanisms

It appears that a particular magnitude of μ opiate receptor activation produces a state to which a memory trace can be confined in a highly selective manner.
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Noradrenaline provides long‐term protection to dopaminergic neurons by reducing oxidative stress

The model of mesencephalic cultures supports the concept that central noradrenergic mechanisms have a neuroprotective role, perhaps in part by reducing oxidative stress.
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The Alpha2-Adrenoceptor Antagonist Dexefaroxan Enhances Hippocampal Neurogenesis by Increasing the Survival and Differentiation of New Granule Cells

By promoting the survival of new endogenously formed neurons, dexefaroxan treatment represents a potential therapeutic strategy for maintaining adult neurogenesis in neurodegenerative conditions, such as Alzheimer's disease, that affect the hippocampus.
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Noradrenaline depletion exacerbates MPTP-induced striatal dopamine loss in mice.

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NMDA antagonists make learning and recall state-dependent.

The data do not support the widely held notion that NMDA antagonists produce deficits in memory or retention; instead, at doses considerably lower than those impairing acquisition, NMda antagonists produce a state upon which the recall of the newly learned response is dependent.
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Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.

The effects on apomorphine-induced circling indicate an influence of alpha-2 adrenoceptor compounds on nigrostriatal neurotransmission at sites downstream from the dopaminergic neurons themselves.
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Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects.

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