Noradrenergic mechanisms in neurodegenerative diseases: a theory
Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus…
Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat
- F. Colpaert
- Biology, PsychologyNeuropharmacology
- 1 September 1987
Opiate States of Memory: Receptor Mechanisms
It appears that a particular magnitude of μ opiate receptor activation produces a state to which a memory trace can be confined in a highly selective manner.
Noradrenaline provides long‐term protection to dopaminergic neurons by reducing oxidative stress
The model of mesencephalic cultures supports the concept that central noradrenergic mechanisms have a neuroprotective role, perhaps in part by reducing oxidative stress.
The Alpha2-Adrenoceptor Antagonist Dexefaroxan Enhances Hippocampal Neurogenesis by Increasing the Survival and Differentiation of New Granule Cells
By promoting the survival of new endogenously formed neurons, dexefaroxan treatment represents a potential therapeutic strategy for maintaining adult neurogenesis in neurodegenerative conditions, such as Alzheimer's disease, that affect the hippocampus.
Noradrenaline depletion exacerbates MPTP-induced striatal dopamine loss in mice.
NMDA antagonists make learning and recall state-dependent.
The data do not support the widely held notion that NMDA antagonists produce deficits in memory or retention; instead, at doses considerably lower than those impairing acquisition, NMda antagonists produce a state upon which the recall of the newly learned response is dependent.
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
- P. Chopin, F. Colpaert, M. Marien
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 February 1999
The effects on apomorphine-induced circling indicate an influence of alpha-2 adrenoceptor compounds on nigrostriatal neurotransmission at sites downstream from the dopaminergic neurons themselves.