Receptors, Opioid, kappa

Known as: Receptors, kappa, kappa receptors, Receptors, kappa Opioid 
A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins… (More)
National Institutes of Health

Related topics

Related topics

11 relations
DynorphinsIn Bloodagonistsantagonists & inhibitors
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Broader (1)

Opioid Receptor

Narrower (3)

Ro1 protein, syntheticRo2 protein, recombinantkappa(1) opioid receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Stress is a complex human experience having both positive and negative motivational properties. When chronic and uncontrollable… (More)
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Highly Cited
2003
Highly Cited
2003
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.
Previous studies have demonstrated that stress may increase prodynorphin gene expression, and kappa opioid agonists suppress drug… (More)
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Highly Cited
2002
Highly Cited
2002
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A, is a hallucinogenic plant in the mint… (More)
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Highly Cited
1994
Highly Cited
1994
ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization.
Selective PCR amplification of human and mouse genomic DNAs with oligonucleotides encoding highly conserved regions of the delta… (More)
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Highly Cited
1994
Highly Cited
1994
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study.
The mu, delta, and kappa opioid receptors are the three main types of opioid receptors found in the central nervous system (CNS… (More)
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Highly Cited
1992
Highly Cited
1992
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
The mesolimbic dopaminergic system has been implicated in mediating the motivational effects of opioids and other drugs of abuse… (More)
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Highly Cited
1988
Highly Cited
1988
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus… (More)
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Highly Cited
1987
Highly Cited
1987
Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain : A. Mansour H. Khachaturian, M.E. Lewis, H. Akil and S.J. Watson, Neuroscience, 7 (1987…
While there is an abundance of pharmacological and biochemical evidence to suggest the existence of multiple opioid receptors… (More)
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Highly Cited
1986
Highly Cited
1986
Psychotomimesis mediated by kappa opiate receptors.
The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions… (More)
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Highly Cited
1985
Highly Cited
1985
Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
The reinforcing properties of various opioid agonists acting preferentially on the kappa and mu opioid receptors were assessed… (More)
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