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Cannabinoid receptor localization in brain.
- M. Herkenham, A. Lynn, K. Rice
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 March 1990
The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.
Amphetamine‐type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
In vitro methods determined the neurochemical mechanism of action of amphetamine, 3,4‐methylenedioxymethamphetamine (MDMA), (+)‐methamphetamine, ephedrine, phentermine, and aminorex, and demonstrated that the most potent effect of these stimulants is to release NE.
Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat
A role of VTA CRF-BP is revealed and an involvement of CRF2R is suggested in the effectiveness of stress in triggering glutamate and dopamine release and cocaine seeking in drug-experienced animals.
Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for κ opioid receptors and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
- B. Roth, K. Baner, R. Rothman
- Biology, PsychologyProceedings of the National Academy of Sciences…
Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for kappa opioid receptors, and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity
- W. Fantegrossi, Brenda M Gannon, S. Zimmerman, K. Rice
- Biology, PsychologyNeuropsychopharmacology
- 1 March 2013
Although the interoceptive effects of MDPV are similar to those of MDMA and METH, direct effects on thermoregulatory processes and locomotor activity are likely mediated by different mechanisms than those of ecstasy.
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.
Evidence that opioids may have toll-like receptor 4 and MD-2 effects