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Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats
TLDR
It is suggested that new pharmacotherapeutic agents that produce augmentations of NAC GLU or PFC DA activity, or perhaps inhibition of PFC GLU activity, may someday be useful for the treatment of METH addiction.
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Kappa opioid inhibition of morphine and cocaine self-administration in rats
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Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum
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U50,488, a κ opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats
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Effects and aftereffects of ibogaine on morphine self-administration in rats.
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Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment
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Rotational movement (circling) in normal humans: sex difference and relationship to hand, foot and eye preference
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Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization
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18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
TLDR
The data suggest that 18‐MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine, and is likely to have an active metabolite.
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Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration.
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