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Tissue Concentrations of Clozapine and its Metabolites in the Rat
A week of daily dosing with CLZ led to no accumulation of drug in brain; a week of fluoxetine pretreatment increased analyte concentrations (serum, 86%; brain, 61%), but valproate had little effect. Expand
Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features.
OBJECTIVE Psychotic affective disorders are the most prevalent idiopathic psychoses, but their outcome from onset has rarely been studied. In this study, the authors determined the rate and latencyExpand
Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
SalvA data provide additional support for the hypothesis that stimulation of brain κ-opioid receptors triggers depressive-like signs in rats and raise the possibility that decreases in extracellular concentrations of DA within the NAc contribute to these effects. Expand
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder.
Findings support the hypothesis that the limbic system, in particular the hippocampus, may be involved in the pathophysiology of pediatric bipolar disorder. Expand
Default mode network abnormalities in bipolar disorder and schizophrenia
The higher frequency of BOLD signal oscillations observed in patients suggests abnormal functional organization of circuits in both disorders and further studies are needed to determine how these abnormalities are related to specific symptoms of each condition. Expand
Behavioral and Anatomical Interactions between Dopamine and Corticotropin-Releasing Factor in the Rat
Male Sprague Dawley rats were used to examine the behavioral effects of altering dopamine transmission on CRF-enhanced startle, a behavioral assay believed to reflect stress- or anxiety-like states, and compounds with D1 receptor antagonist properties might have anxiolytic-like effects that could be useful for treating conditions associated with hyperactive CRF systems. Expand
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
A previously uncharacterized and common A/T polymorphism at −3081 upstream of the transcription initiation site of the human norepinephrine transporter gene is reported, suggesting that anomalous transcription factor-based repression of SLC6A2 may increase risk for the development of attention-deficit hyperactivity disorder and other neuropsychiatric diseases. Expand
Cognitive variability in psychotic disorders: a cross-diagnostic cluster analysis
Identification of groups of patients who share similar neurocognitive profiles may help pinpoint relevant neural abnormalities underlying these traits, and hasten the development of individualized treatment approaches, including cognitive remediation tailored to patients' specific cognitive profiles. Expand
Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans
SA produced a wide range of transient effects in healthy subjects, including dissociative and somaesthetic effects, increased plasma cortisol and prolactin, and reduced resting electroencephalogram spectral power, suggesting a low addictive potential similar to other hallucinogens and consistent with κ opiate receptor agonism. Expand
Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia
Functional connectivity between MPFC and insula/VLPFC distinguished bipolar disorder from schizophrenia, and may reflect differences in the affective disturbances typical of each illness. Expand