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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.

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Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

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A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.

TLDR
The p130 (designated Cas for Crk‐associated substrate) is a common cellular target of phosphorylation signal via v‐Crk and v‐Src oncoproteins, and its unique structure indicates the possible role of p130Cas in assembling signals from multiple SH2‐containing molecules.
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Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

TLDR
It is shown that in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis, bone-marrow cells give rise to most of the SMCs that contribute to arterial remodeling, indicating that somatic stem cells contribute to pathological remodeling of remote organs.
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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

TLDR
In the absence of AML-1, hematopoietic progenitors were fully maintained with normal myeloid cell development, however, AMl-1-deficient bone marrow showed inhibition of megakaryocytic maturation, increased hematoplastic progenitor cells and defective T- and B-lymphocyte development.
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Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.

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Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.

TLDR
Characterization of the genomic structure revealed that the AML1 gene consists of nine exons and spans > 150 kb of genomic DNA, which can all be explained by the existence of two promoters, alternative splicing and differential usage of three polyadenylation sites.
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Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

TLDR
It is shown that growth hormone stimulates tyrosine phosphorylation of the receptor for epidermal growth factor (EGFR) and its association with Grb2 and at the same time stimulates MAP kinase activity in liver, an important target tissue of growth hormone.
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Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes,…
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Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

TLDR
Findings have defined Cas function in cardiovascular development, actin filament assembly and Src-induced transformation in cells transformed by v-Src or v-Crk.
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