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Function and activation of NF-kappa B in the immune system.
TLDR
The inhibition of NF-kappa B activation by antioxidants and specific protease inhibitors may provide a pharmacological basis for interfering with these acute processes in suppressing toxic/septic shock, graft-vs-host reactions, acute inflammatory reactions, severe phase response, and radiation damage. Expand
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
TLDR
It is shown that micromolar concentrations of H2O2 can induce the expression and replication of HIV‐1 in a human T cell line and suggests that diverse agents thought to activate NF‐kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI. Expand
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
TLDR
It is shown that dithiocarbamates and metal chelators can potently block the activation of nuclear factor kappa B (NF-kappa B), a transcription factor involved in human immunodeficiency virus type 1 (HIV-1) expression, signaling, and immediate early gene activation during inflammatory processes. Expand
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review).
TLDR
The evidences that NF-kappa B is an oxidative stress-responsive transcription factor of higher eukaryotic cells are discussed, including that antioxidants not only suppress the activation of NF- kappa B by H2O2 but by all other inducers tested so far. Expand
Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody
TLDR
The clinical activity of a bispecific antibody construct called blinatumomab, which has the potential to engage all cytotoxic T cells in patients for lysis of cancer cells, is reported on. Expand
I kappa B: a specific inhibitor of the NF-kappa B transcription factor.
TLDR
The data show the existence of a phorbol ester-responsive regulatory protein that acts by controlling the DNA binding activity and subcellular localization of a transcription factor in cells that do not express immunoglobulin kappa light chain genes. Expand
NF-κB: Ten Years After
TLDR
The manuscript and the Figures and Table are based on a manuscript originally written by Gordon C. Dickinson in 2012 and then edited by David I. Dickinson and revised by David A. Dickinson. Expand
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate
TLDR
T cells engaged by blinatumomab seem capable of eradicating chemotherapy-resistant tumor cells that otherwise cause clinical relapse in patients with MRD-positive B-lineage ALL after intensive chemotherapy. Expand
Nuclear signalling by tumour-associated antigen EpCAM
TLDR
It is shown that regulated intramembrane proteolysis activates EpCAM as a mitogenic signal transducer in vitro and in vivo and explains howEpCAM functions in cell proliferation. Expand
H2O2 and antioxidants have opposite effects on activation of NF‐kappa B and AP‐1 in intact cells: AP‐1 as secondary antioxidant‐responsive factor.
TLDR
It is shown that AP‐1 is an antioxidant‐responsive transcription factor that is induced in HeLa cells upon treatment with the antioxidants pyrrolidine dithiocarbamate and N‐acetyl‐L‐cysteine, and upon transient expression of the antioxidative enzyme thioredoxin. Expand
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