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International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors
A review of the calcitonin family of peptides aims to reconcile what is observed when the receptors are reconstituted in vitro with the properties they show in native cells and tissues. Expand
XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
Based on structural and evolutionary criteria, neuropeptide Y (NPY)b, peptide YY (PYY) and pancreatic polypetide (PP) are closely related polypeptides that share considerable amino acid homology, amidated C-terminal ends, and the same structure. Expand
Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity
Results are provided suggesting that slow‐firing cholinergic, fast‐f firing and burst-firing GABAergic, and cluster‐fired glutamatergic neurons, may each uniquely contribute to hippocampal rhythmicity in vivo. Expand
Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors
Findings on the anatomical distributions of CGRP mRNA, C GRP-like immunoreactivity and receptors in the central nervous system, as well as the potential physiological roles for CGRp are discussed. Expand
The effects of chronic antidepressant treatment in an animal model of anxiety
It is suggested that antidepressants acquire anxiolytic properties following chronic administration and that this effect appears to be independent of the benzodiazepine receptor system. Expand
A proposal for the classification of sigma binding sites.
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.
Data obtained from the generation of an NPY-transgenic rat support and extend a previously postulated anti-stress action of NPY and provide novel evidence for a role ofNPY in learning and memory. Expand
hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery.
The C-terminal fragment of human calcitonin gene-related peptide, hCGRP8-37, fails to induce any biological activity in a variety of isolated tissues and behavioral assays even though it possesses nanomolar affinity for [125I]hC GRP alpha binding sites in the central nervous system and peripheral membrane preparations, which suggests the existence of at least two classes of CGRP receptors. Expand
Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity.
The ligand selectivity profile observed in this study suggests that [125I] hCGRP binding sites present in rat brain and spleen are similar and it appears that it is possible to differentiate between CGRP receptor subtypes on the basis of differential agonistic and antagonistic potencies in various isolated tissues. Expand
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2High states is found, it suggests that there are many pathways to psychosis, any one of which can be disrupted. Expand