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Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development…
- J. Leysen
- BiologyCurrent drug targets. CNS and neurological…
- 31 January 2004
Select aspects of 5-HT(2) receptor research are reviewed for each subtype under three main headings : (i) genes, protein structure and receptor signaling; (ii) receptor localization with emphasis on the CNS and (iii) compounds.
[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.
5-HT2A and 5-HT2C receptors and their atypical regulation properties.
Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.
- J. Leysen, W. Gommeren, P. van Gompel, J. Wynants, P. Janssen, P. Laduron
- Biology, MedicineMolecular pharmacology
- 1 June 1985
In vivo binding assays using [3H]spiperone confirmed the occupation of frontal cortical serotonin-S2 sites following low dosage of ritanserin and a minor occupation of striatal dopamine-D2 sites.
Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography
Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.
The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.
Expression and regulation of interleukin‐10 and interleukin‐10 receptor in rat astroglial and microglial cells
The concept that IL‐10, produced by activated microglial and astroglial cells, modulates glia‐mediated inflammatory responses through high‐affinity IL‐ 10 receptors via paracrine and autocrine interactions is supported.
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
- H. Lavreysen, C. Janssen, F. Bischoff, X. Langlois, J. Leysen, A. Lesage
- Biology, ChemistryMolecular pharmacology
- 1 May 2003
The high affinity and selectivity of [(3)H]R214127 for mGlu1 receptors renders this compound the ligand of choice to study the native mGLU1 receptor in brain.