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Norfenfluramine

Known as: Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-, Norfenfluramine [Chemical/Ingredient] 
A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

Dexnorfenfluraminehydroxyethylnorfenfluramine

Broader (3)

FenfluramineSerotonin AgentsSerotonin Uptake Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia… 
Highly Cited
2000
Highly Cited
2000
Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
Background—Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being… 
Highly Cited
2000
Highly Cited
2000
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be… 
Highly Cited
1999
Highly Cited
1999
Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells
The goal of this study was to characterize the agonist pharmacology of human 5‐HT2A, 5‐HT2B and 5‐HT2C (VSV) receptors expressed… 
Review
1997
Review
1997
Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability.
Highly Cited
1993
Highly Cited
1993
Effects of serotonin and the serotonin blocker metergoline on meal patterns and macronutrient selection
Review
1992
Review
1992
Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity.
Dexfenfluramine stimulates serotoninergic activity by inhibiting serotonin reuptake into presynaptic neurons and by enhancing its… 
Highly Cited
1988
Highly Cited
1988
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)
  • M. D. Schechter
  • Pharmacology Biochemistry and Behavior
  • 1988
  • Corpus ID: 30813576
Highly Cited
1986
Highly Cited
1986
Hypothalamic serotonin in the control of meal patterns and macronutrient selection
Highly Cited
1986
Highly Cited
1986
Medial hypothalamic serotonin: Effects on deprivation and norepinephrine-induced eating
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