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Norfenfluramine
Known as:
Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-
, Norfenfluramine [Chemical/Ingredient]
A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental…
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National Institutes of Health
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Related topics
Related topics
12 relations
Narrower (2)
Dexnorfenfluramine
hydroxyethylnorfenfluramine
Broader (3)
Fenfluramine
Serotonin Agents
Serotonin Uptake Inhibitors
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
V. Setola
,
S. Hufeisen
,
+5 authors
B. Roth
Molecular pharmacology
2003
Corpus ID: 839426
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia…
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Highly Cited
2000
Highly Cited
2000
Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
R. Rothman
,
M. Baumann
,
+4 authors
B. Roth
Circulation
2000
Corpus ID: 2378043
Background—Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being…
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Highly Cited
2000
Highly Cited
2000
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
L. Fitzgerald
,
T. Burn
,
+13 authors
D. Robertson
Molecular pharmacology
2000
Corpus ID: 22715350
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be…
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Highly Cited
1999
Highly Cited
1999
Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells
R. Porter
,
K. Benwell
,
+5 authors
M. Sheardown
British journal of pharmacology
1999
Corpus ID: 8104853
The goal of this study was to characterize the agonist pharmacology of human 5‐HT2A, 5‐HT2B and 5‐HT2C (VSV) receptors expressed…
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Review
1997
Review
1997
Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability.
G. Curzon
,
E. Gibson
,
A. O. Oluyomi
Trends in pharmacological sciences
1997
Corpus ID: 12470950
Highly Cited
1993
Highly Cited
1993
Effects of serotonin and the serotonin blocker metergoline on meal patterns and macronutrient selection
S. Leibowitz
,
J. Alexander
,
W. K. Cheung
,
G. F. Weiss
Pharmacology Biochemistry and Behavior
1993
Corpus ID: 122800
Review
1992
Review
1992
Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity.
D. McTavish
,
R. Heel
Drugs
1992
Corpus ID: 195693054
Dexfenfluramine stimulates serotoninergic activity by inhibiting serotonin reuptake into presynaptic neurons and by enhancing its…
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Highly Cited
1988
Highly Cited
1988
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)
M. D. Schechter
Pharmacology Biochemistry and Behavior
1988
Corpus ID: 30813576
Highly Cited
1986
Highly Cited
1986
Hypothalamic serotonin in the control of meal patterns and macronutrient selection
G. Shor‐Posner
,
J. Grinker
,
Constantine Marinescu
,
O. Brown
,
S. Leibowitz
Brain Research Bulletin
1986
Corpus ID: 4766284
Highly Cited
1986
Highly Cited
1986
Medial hypothalamic serotonin: Effects on deprivation and norepinephrine-induced eating
G. F. Weiss
,
P. Papadakos
,
K. Knudson
,
S. Leibowitz
Pharmacology Biochemistry and Behavior
1986
Corpus ID: 37240444
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