FAQ

Norfenfluramine

Known as: Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-, Norfenfluramine [Chemical/Ingredient] 
A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
051019702017

Related topics

Related topics

12 relations

Narrower (2)

Dexnorfenfluraminehydroxyethylnorfenfluramine

Broader (3)

FenfluramineSerotonin AgentsSerotonin Uptake Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Norfenfluramine
Serotonin Uptake Inhibitors
In Blood
chemical synthesis
Fenfluramine
Serotonin Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.
S-(+)-Norfenfluramine (SNF)-an active metabolite of the now-banned anorexigen fenfluramine-has been implicated in the drug's… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 2
Is this relevant?
Highly Cited
2003
Highly Cited
2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors.
The present series of studies is the first to investigate the pharmacological mechanisms underlying d-fenfluramine- and d… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
BACKGROUND Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.
1. The goal of this study was to characterize the agonist pharmacology of human 5-HT2A, 5-HT2B and 5-HT2C (VSV) receptors… (More)
Is this relevant?
1998
1998
Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential.
N-Ethyl-5-trifluoromethyl-2-aminoindan (ETAI) and 5-trifluoromethyl-2-aminoindan (TAI) were synthesized to examine the effects of… (More)
Is this relevant?
1993
1993
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.
Severe depletion of 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine (pCPA, 150 mg/kg per day x3) did not alter the… (More)
Is this relevant?
1990
1990
Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat.
Previous research with hypothalamic injection of serotonin (5-HT) has suggested that this monoamine may act within the medial… (More)
Is this relevant?
1983
1983
Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms.
The abilities of d-fenfluramine (d-F) and that of d-norfenfluramine (d-NF) to inhibit [3H]serotonin ([3H]5-HT) accumulation in… (More)
Is this relevant?