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Norfenfluramine

Known as: Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-, Norfenfluramine [Chemical/Ingredient] 
A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental… Expand
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

Dexnorfenfluraminehydroxyethylnorfenfluramine

Broader (3)

FenfluramineSerotonin AgentsSerotonin Uptake Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia… Expand
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Highly Cited
2001
Highly Cited
2001
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
The present series of studies is the first to investigate the pharmacological mechanisms underlying d-fenfluramine- and d… Expand
Highly Cited
2000
Highly Cited
2000
Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
Background—Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being… Expand
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Highly Cited
2000
Highly Cited
2000
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be… Expand
Highly Cited
1999
Highly Cited
1999
Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells
The goal of this study was to characterize the agonist pharmacology of human 5‐HT2A, 5‐HT2B and 5‐HT2C (VSV) receptors expressed… Expand
Highly Cited
1993
Highly Cited
1993
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.
Severe depletion of 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine (pCPA, 150 mg/kg per day x3) did not alter the… Expand
Review
1992
Review
1992
Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity.
Dexfenfluramine stimulates serotoninergic activity by inhibiting serotonin reuptake into presynaptic neurons and by enhancing its… Expand
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Highly Cited
1990
Highly Cited
1990
Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine
The optical isomers of fenfluramine and norfenfluramine were administered to rats to examine their relative potency for… Expand
Highly Cited
1990
Highly Cited
1990
Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat
Previous research with hypothalamic injection of serotonin (5-HT) has suggested that this monoamine may act within the medial… Expand
Highly Cited
1982
Highly Cited
1982
D-Fenfluramine and D-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain.
Summary The anorectic effect of d-norfenfluramine, but not that of d-fenfluramine, was potentiated in reserpine-treated rats… Expand
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