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Norfenfluramine

Known as: Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-, Norfenfluramine [Chemical/Ingredient] 
A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental… Expand
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

Dexnorfenfluraminehydroxyethylnorfenfluramine

Broader (3)

FenfluramineSerotonin AgentsSerotonin Uptake Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine.
The trifluoromethyl group of fluoxetine 1 and fenfluramine and norfenfluramine, 2 and 3, was substituted by the… Expand
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2005
2005
Molecular Determinants for the Interaction of the Valvulopathic Anorexigen Norfenfluramine with the 5-HT2B Receptor
S-(+)-Norfenfluramine (SNF)—an active metabolite of the now-banned anorexigen fenfluramine—has been implicated in the drug's… Expand
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2004
2004
Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and dl-fenfluramine for 15 days
SummaryThe kinetics of accumulation and elimination of d- and l-fenfluramine (F) and norfenfluramine (NF) have been studied in 8… Expand
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Highly Cited
2003
Highly Cited
2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia… Expand
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Highly Cited
2001
Highly Cited
2001
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
The present series of studies is the first to investigate the pharmacological mechanisms underlying d-fenfluramine- and d… Expand
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Highly Cited
2000
Highly Cited
2000
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
BACKGROUND Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being… Expand
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Highly Cited
2000
Highly Cited
2000
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be… Expand
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Highly Cited
1999
Highly Cited
1999
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.
1. The goal of this study was to characterize the agonist pharmacology of human 5-HT2A, 5-HT2B and 5-HT2C (VSV) receptors… Expand
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1993
1993
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.
Severe depletion of 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine (pCPA, 150 mg/kg per day x3) did not alter the… Expand
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1990
1990
Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat
Previous research with hypothalamic injection of serotonin (5-HT) has suggested that this monoamine may act within the medial… Expand
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