• Publications
  • Influence
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such asExpand
  • 1,608
  • 115
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Recent years have witnessed the rise of the gut microbiota as a major topic of research interest in biology. Studies are revealing how variations and changes in the composition of the gut microbiotaExpand
  • 1,889
  • 96
Assessing antidepressant activity in rodents: recent developments and future needs.
Animal models are indispensable tools in the search to identify new antidepressant drugs and to provide insights into the neuropathology that underlies the idiopathic disease state of depression. AsExpand
  • 1,376
  • 81
Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressant class today and exert their antidepressant-like effects by increasing synaptic concentrations ofExpand
  • 915
  • 72
The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice
Since its introduction almost 20 years ago, the tail suspension test has become one of the most widely used models for assessing antidepressant-like activity in mice. The test is based on the factExpand
  • 1,022
  • 67
Model organisms: The ascent of mouse: advances in modelling human depression and anxiety
Psychiatry has proven to be among the least penetrable clinical disciplines for the development of satisfactory in vivo model systems for evaluating novel treatment approaches. However, mood andExpand
  • 715
  • 42
Using the rat forced swim test to assess antidepressant-like activity in rodents
The forced swim test (FST) is one of the most commonly used animal models for assessing antidepressant-like behavior. This protocol details using the FST in rats, which takes place over 48 h and isExpand
  • 431
  • 42
Microbiota and neurodevelopmental windows: implications for brain disorders.
Gut microbiota is essential to human health, playing a major role in the bidirectional communication between the gastrointestinal tract and the central nervous system. The microbiota undergoes aExpand
  • 492
  • 35
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Bacterial colonisation of the intestine has a major role in the post-natal development and maturation of the immune and endocrine systems. These processes are key factors underpinning central nervousExpand
  • 760
  • 34
A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS. These receptors consist of two domains, anExpand
  • 214
  • 28