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Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
TLDR
Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis. Expand
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
TLDR
The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders. Expand
Assessing antidepressant activity in rodents: recent developments and future needs.
TLDR
This review focuses on recent findings regarding some of the most widely employed animal models used currently to predict antidepressant potential, and emphasis is placed on recent modifications to such paradigms that have increased their utility and reliability. Expand
Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test
TLDR
A physiological model of performance in the rat FST has been proposed involving the regulation of 5-HT transmission by corticotropin releasing factor (CRF), which is based on extensive evaluation of agonists and antagonists of individual 5- HT receptor subtypes. Expand
The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice
TLDR
The tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression. Expand
Using the rat forced swim test to assess antidepressant-like activity in rodents
TLDR
This protocol details using the FST in rats, which takes place over 48 h and is followed by the video analysis of the behavior, which indicates reduction in passive behavior is interpreted as an antidepressant-like effect of the manipulation. Expand
Microbiota and neurodevelopmental windows: implications for brain disorders.
TLDR
The concept of parallel and interacting microbial-neural critical windows opens new avenues for developing novel microbiota-modulating based therapeutic interventions in early life to combat neurodevelopmental deficits and brain disorders. Expand
Model organisms: The ascent of mouse: advances in modelling human depression and anxiety
TLDR
The current status of research into developing appropriate tests for assessing depression- and anxiety-related behaviours in mice is assessed. Expand
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
TLDR
It is demonstrated that CNS neurotransmission can be profoundly disturbed by the absence of anormal gut microbiota and that this aberrant neurochemical, but not behavioural, profile is resistant to restoration of a normal gut flora in later life. Expand
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
TLDR
Therapeutic targeting of the gut microbiota might be a viable treatment strategy for serotonin-related brain-gut axis disorders. Expand
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