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The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice.
TLDR
The results show that arcuate NPY neurons, identified by the presence of AGRP, project more extensively in the brain than previously known and indicate that the feeding regulatory actions of NPY may extend beyond the hypothalamus. Expand
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.
TLDR
The results suggest that lipid-soluble tetracyclines, doxycycline and minocycline, inhibit inflammation and are neuroprotective against ischemic stroke, even when administered after the insult. Expand
Hypocretin/Orexin‐ and melanin‐concentrating hormone‐expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene‐related protein
TLDR
Evidence is provided for an arcuate‐lateral hypothalamic neuropeptide Y/agouti gene‐related protein pathway and implicate hypocretin/orexin and melanin‐concentrating hormone‐expressing cells as downstream targets in neuropeptic Y‐induced feeding. Expand
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
TLDR
Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed, thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron. Expand
High nitric oxide production in human paranasal sinuses
TLDR
It is reported that NO in humans is produced by epithelial cells in the paranasal sinuses and is present in sinus air in very high concentrations, close to the highest permissible atmospheric pollution levels. Expand
Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study
TLDR
The present study justifies the pharmacological subclassification ofalpha‐2 receptors by providing anatomical evidence for specific and selective cell groups in the rat central nervous system containing mRNA for three alpha‐2 receptor subtypes. Expand
Neuropeptides — an overview
TLDR
It seems that peptides may play a role particularly when the nervous system is stressed, challenged or afflicted by disease, and that peptidergic systems may, therefore, be targets for novel therapeutic strategies. Expand
Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy
TLDR
Some primary sensory neurons react to transection of their peripheral branches by expressing increased GAL levels, and this reaction has been described by other groups for vasoactive intestinal polypeptide. Expand
Nitric oxide synthase‐like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy
TLDR
It is demonstrated that axotomy in rat induces a marked upregulation of NOS synthesis in primary sensory neurons, thus suggesting a role for NO in lesioned sensory neurons. Expand
Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: A putative mediator of cholecystokinin-induced satiety.
TLDR
The present results suggest that CART-derived peptides are present in vagal afferent neurons sensitive to cholecystokinin, suggesting that the role of these peptides in feeding may be explained partly by mediating postprandial satiety effects of chole cysteine. Expand
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