Share This Author
How to increase value and reduce waste when research priorities are set
Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers
- J. Adamski, B. Godman, L. Gustafsson
- Medicine, Political ScienceBMC health services research
- 7 June 2010
There are only a limited number of situations where 'risk sharing' schemes should be considered as well as factors thatShould be considered by payers in advance of implementation, and whether systematic evaluations have been built into proposed schemes.
Prognosis of untreated patients with idiopathic membranous nephropathy
Most untreated patients with idiopathic membranous nephropathy maintain renal function for prolonged periods and are likely to have spontaneous remission, and these results do not support the use of glucocorticoids and immunosuppressive drugs in patients with the disorder.
Caffeine disposition after oral doses
- M. Bonati, R. Latini, F. Galletti, John F. Young, G. Tognoni, S. Garattini
- Chemistry, MedicineClinical pharmacology and therapeutics
- 1 July 1982
The results indicate that TMX exhibits dose‐independent kinetics at the levels at which man normally takes TMX, and this profile of TMX disposition in the healthy adult is provided.
Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
Brain concentrations reflected the plasma kinetics of FL and NFL and the metabolite-to-parent drug ratio varied with dose and time of administration and was modified at the highest dose tested.
Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouse.
Effects of new smoking regulations in Italy.
- S. Gallus, P. Zuccaro, C. la Vecchia
- Medicine, Political ScienceAnnals of oncology : official journal of the…
- 1 February 2006
The results of the study on the first extensive smoking ban in a large country show the advantages of smoke-free legislations, which may have major public health implications.
Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
The induction of spontaneously recurring seizures in rats involves the activation of inflammatory cytokines and related pro‐ and anti‐inflammatory genes in the hippocampus and these changes may play an active role in hyperexcitability of the epileptic tissue.
Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium
A review discusses how internists might tackle the new challenges of the aging population and the development of new approaches in the frame of undergraduate and postgraduate training and of clinical research is essential to improve and implement suitable strategies.
Cellular retention, cytotoxicity and morphological transformation by vanadium(IV) and vanadium(V) in BALB/3T3 cell lines.
Cytotoxicity, morphological transformation and cellular retention have been studied in BALB/3T3 Cl A 31-1-1 cells and corresponding gel-filtration experiments indicate that a redistribution of the element among the cytosol components occurs with time.