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Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers
TLDR
There are only a limited number of situations where 'risk sharing' schemes should be considered as well as factors thatShould be considered by payers in advance of implementation, and whether systematic evaluations have been built into proposed schemes. Expand
How to increase value and reduce waste when research priorities are set
TLDR
This report discusses how avoidable waste can be considered when research priorities are set and recommends ways to improve the yield from basic research, and the transparency of processes by which funders prioritise important uncertainties should be increased. Expand
Caffeine disposition after oral doses
TLDR
The results indicate that TMX exhibits dose‐independent kinetics at the levels at which man normally takes TMX, and this profile of TMX disposition in the healthy adult is provided. Expand
Prognosis of untreated patients with idiopathic membranous nephropathy
TLDR
Most untreated patients with idiopathic membranous nephropathy maintain renal function for prolonged periods and are likely to have spontaneous remission, and these results do not support the use of glucocorticoids and immunosuppressive drugs in patients with the disorder. Expand
Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
TLDR
Brain concentrations reflected the plasma kinetics of FL and NFL and the metabolite-to-parent drug ratio varied with dose and time of administration and was modified at the highest dose tested. Expand
Effects of new smoking regulations in Italy.
TLDR
The results of the study on the first extensive smoking ban in a large country show the advantages of smoke-free legislations, which may have major public health implications. Expand
Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium
TLDR
A review discusses how internists might tackle the new challenges of the aging population and the development of new approaches in the frame of undergraduate and postgraduate training and of clinical research is essential to improve and implement suitable strategies. Expand
Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
TLDR
The induction of spontaneously recurring seizures in rats involves the activation of inflammatory cytokines and related pro‐ and anti‐inflammatory genes in the hippocampus and these changes may play an active role in hyperexcitability of the epileptic tissue. Expand
Tianeptine, a selective enhancer of serotonin uptake in rat brain
TLDR
The biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. Expand
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