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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TLDR
It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation. Expand
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
TLDR
The basolateral amygdala (BLA) appears to be required for a Pavlovian conditioned stimulus to gain access to the current value of the specific unconditioned stimulus (US) that it predicts, while the central nucleus of the amygdala acts as a controller of brainstem arousal and response systems, and subserves some forms of stimulus-response Pavlovia conditioning. Expand
Impulsivity, Compulsivity, and Top-Down Cognitive Control
TLDR
The results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype, and characterize in neurobehavioral and neurochemical terms a rodent model of impulsivity based on premature responding in an attentional task. Expand
Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement
TLDR
It is reported that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine function before drug exposure, and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences. Expand
Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation
TLDR
By infusing antisense oligodeoxynucleotides into the hippocampus of rats, this work shows that consolidation and reconsolidation are doubly dissociable component processes of memory. Expand
The effects of d-amphetamine, chlordiazepoxide, α-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats
TLDR
Signals present during a delay can enhance the ability of amphetamine to promote choice of delayed rewards and speed up cue speeded learning. Expand
High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
TLDR
Experimental evidence is shown that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction. Expand
Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation
TLDR
Investigation of the effects of enhancing and blocking NMDA receptor-mediated glutamatergic transmission on the reconsolidation and extinction of a conditioned fear memory showed that the basolateral amygdala is a primary locus of action of systemically administered DCS, and memory reconsolidations can be both disrupted and enhanced. Expand
Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core
TLDR
It is shown that selective lesions of the nucleus accumbens core induce persistent impulsive choice in rats, and damage to two of its afferents, the anterior cingulate cortex and medial prefrontal cortex, had no effect on this capacity. Expand
Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective
TLDR
Although intense white noise failed to produce differential impairments when presented simultaneously with the visual discriminanda, the DNAB lesion significantly impaired accuracy when the noise was presented immediately prior to, but not overlapping, the onset of the visual stimuli. Expand
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