Share This Author
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Impulsivity, Compulsivity, and Top-Down Cognitive Control
Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation
By infusing antisense oligodeoxynucleotides into the hippocampus of rats, this work shows that consolidation and reconsolidation are doubly dissociable component processes of memory.
Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement
It is reported that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine function before drug exposure, and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences.
The effects of d-amphetamine, chlordiazepoxide, α-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats
Signals present during a delay can enhance the ability of amphetamine to promote choice of delayed rewards and speed up cue speeded learning.
High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
Experimental evidence is shown that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.
Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation
- Jonathan L. C. Lee, A. Milton, B. Everitt
- Biology, PsychologyThe Journal of Neuroscience
- 27 September 2006
Investigation of the effects of enhancing and blocking NMDA receptor-mediated glutamatergic transmission on the reconsolidation and extinction of a conditioned fear memory showed that the basolateral amygdala is a primary locus of action of systemically administered DCS, and memory reconsolidations can be both disrupted and enhanced.
Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core
- R. Cardinal, David R. Pennicott, C. Lakmali, Sugathapala, T. Robbins, B. Everitt
- Psychology, BiologyScience
- 24 May 2001
It is shown that selective lesions of the nucleus accumbens core induce persistent impulsive choice in rats, and damage to two of its afferents, the anterior cingulate cortex and medial prefrontal cortex, had no effect on this capacity.