Neoplastic Cell Transformation
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Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface… Expand Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro… Expand Many studies have used DNA microarrays to identify the gene expression signatures of human cancer, yet the critical features of… Expand Recent evidence suggests that human cells require more genetic changes for neoplastic transformation than do their murine… Expand The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to… Expand The PI3K/Akt signal transduction cascade has been investigated extensively for its roles in oncogenic transformation. Initial… Expand A plethora of physiological and pathological stimuli induce and activate a group of DNA binding proteins that form AP-1 dimers… Expand The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs… Expand Grasping requires coding of the object's intrinsic properties (size and shape), and the transformation of these properties into a… Expand DEREGULATION of cell proliferation is a hallmark of neoplastic transformation. Alteration in growth control pathways must… Expand