Neoplastic Cell Transformation

Known as: neoplastic transformation, Cell Transformation, Neoplastic, Cell Neoplastic Transformation 
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities… (More)
National Institutes of Health

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AML1/TEL FUSION GENEANP32C protein, humanANP32C wt AlleleARHGEF5 gene
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Broader (1)

metaplastic cell transformation

Papers overview

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Review
2017
Review
2017
Role of tumor microenvironment in tumorigenesis
Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are… (More)
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Review
2017
Review
2017
Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis
Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment… (More)
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Highly Cited
2009
Highly Cited
2009
Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation
Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface… (More)
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Highly Cited
2005
Highly Cited
2005
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
The aggressive clinical behavior of melanoma suggests that the developmental origins of melanocytes in the neural crest might be… (More)
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Highly Cited
2004
Highly Cited
2004
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression.
Many studies have used DNA microarrays to identify the gene expression signatures of human cancer, yet the critical features of… (More)
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Highly Cited
2003
Highly Cited
2003
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.
The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to… (More)
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Review
2003
Review
2003
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
The PI3K/Akt signal transduction cascade has been investigated extensively for its roles in oncogenic transformation. Initial… (More)
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Review
2001
Review
2001
AP-1 in cell proliferation and survival
A plethora of physiological and pathological stimuli induce and activate a group of DNA binding proteins that form AP-1 dimers… (More)
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Highly Cited
1999
Highly Cited
1999
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene occur in most human colon cancers. Loss of functional… (More)
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Highly Cited
1995
Highly Cited
1995
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
In the present study we demonstrate that erbB-3 and erbB-2 cooperate in neoplastic transformation. Under conditions in which… (More)
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