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Neoplastic Cell Transformation

Known as: neoplastic transformation, Cell Transformation, Neoplastic, Cell Neoplastic Transformation 
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities… 
National Institutes of Health

Related topics

Related topics

50 relations
AML1/TEL FUSION GENEANP32C protein, humanANP32C wt AlleleARHGEF5 gene

Broader (1)

metaplastic cell transformation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation
Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface… 
Highly Cited
2005
Highly Cited
2005
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro… 
Highly Cited
2004
Highly Cited
2004
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression.
Many studies have used DNA microarrays to identify the gene expression signatures of human cancer, yet the critical features of… 
Highly Cited
2003
Highly Cited
2003
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to… 
Review
2003
Review
2003
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
The PI3K/Akt signal transduction cascade has been investigated extensively for its roles in oncogenic transformation. Initial… 
Highly Cited
1996
Highly Cited
1996
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
Highly Cited
1995
Highly Cited
1995
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
In the present study we demonstrate that erbB-3 and erbB-2 cooperate in neoplastic transformation. Under conditions in which… 
Review
1995
Review
1995
Grasping objects: the cortical mechanisms of visuomotor transformation
Highly Cited
1994
Highly Cited
1994
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
Highly Cited
1993
Highly Cited
1993
p21 is a universal inhibitor of cyclin kinases
DEREGULATION of cell proliferation is a hallmark of neoplastic transformation. Alteration in growth control pathways must… 
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