• Publications
  • Influence
Toward a Shared Vision for Cancer Genomic Data.
The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic, and clinical outcome data from National Cancer Institute–funded projects. A harmonization process will alignExpand
  • 536
  • 51
  • PDF
Function and regulation of ras.
  • 1,140
  • 36
Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.
Infection by certain human papillomavirus types is regarded as the major risk factor in the development of cervical cancer, one of the most common cancers of women worldwide. Analysis of theExpand
  • 1,029
  • 32
  • PDF
Efficient Intracellular Assembly of Papillomaviral Vectors
ABSTRACT Although the papillomavirus structural proteins, L1 and L2, can spontaneously coassemble to form virus-like particles, currently available methods for production of L1/L2 particles capableExpand
  • 429
  • 28
Carrageenan Is a Potent Inhibitor of Papillomavirus Infection
Certain sexually transmitted human papillomavirus (HPV) types are causally associated with the development of cervical cancer. Our recent development of high-titer HPV pseudoviruses has made itExpand
  • 307
  • 28
  • PDF
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection
Papillomaviruses (PV) comprise a large family of nonenveloped DNA viruses that include the oncogenic PV types that are the causative agents of human cervical cancer. As is true of many animal DNAExpand
  • 290
  • 27
  • PDF
E‐cadherin‐mediated adhesion inhibits ligand‐dependent activation of diverse receptor tyrosine kinases
E‐cadherin is an essential adhesion protein as well as a tumor suppressor that is silenced in many cancers. Its adhesion‐dependent regulation of signaling has not been elucidated. We report thatExpand
  • 349
  • 26
  • PDF
Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18.
Sensitive high-throughput neutralization assays, based upon pseudoviruses carrying a secreted alkaline phosphatase (SEAP) reporter gene, were developed and validated for human papillomavirus (HPV)16,Expand
  • 325
  • 24
  • PDF
Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles.
The L1 genes of two human papillomavirus type 16 (HPV16) isolates derived from condylomata acuminata were used to express the L1 major capsid protein in insect cells via recombinant baculoviruses.Expand
  • 607
  • 20
Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan
Genital human papillomavirus (HPV) infection is the most common sexually transmitted infection, and virtually all cases of cervical cancer are attributable to infection by a subset of HPVs (reviewedExpand
  • 426
  • 20
  • PDF