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The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia
Diamond–Blackfan anaemia (DBA) is a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors. The disease, previously mapped to human chromosome 19q13, isExpand
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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatensExpand
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Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis
Erythropoiesis is the process by which nucleated erythroid progenitors proliferate and differentiate to generate, every second, millions of nonnucleated red cells with their unique discoid shape andExpand
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Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm
Vascular occlusion is the major cause of morbidity and mortality in sickle cell disease but its mechanisms are poorly understood. We demonstrate by using intravital microscopy in mice expressingExpand
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A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane.
We have studied the membrane proteins of band 3 anion exchanger (AE1)-deficient mouse and human red blood cells. It has been shown previously that proteins of the band 3 complex are reduced or absentExpand
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Disorders of red cell membrane
Studies during the last three decades have enabled the development of detailed molecular insights into the structural basis of altered function in various inherited red cell membrane disorders. ThisExpand
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A Maurer's cleft–associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells
The high mortality of Plasmodium falciparum malaria is the result of a parasite ligand, PfEMP1 (P. falciparum) erythrocyte membrane protein 1), on the surface of infected red blood cells (IRBCs),Expand
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Protein 4.1R-dependent multiprotein complex: New insights into the structural organization of the red blood cell membrane
Protein 4.1R (4.1R) is a multifunctional component of the red cell membrane. It forms a ternary complex with actin and spectrin, which defines the nodal junctions of the membrane-skeletal network,Expand
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Erythroblastic islands: niches for erythropoiesis.
Erythroblastic islands, the specialized niches in which erythroid precursors proliferate, differentiate, and enucleate, were first described 50 years ago by analysis of transmission electronExpand
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Structural Protein 4.1 in the Nucleus of Human Cells: Dynamic Rearrangements during Cell Division
Structural protein 4.1, first identified as a crucial 80-kD protein in the mature red cell membrane skeleton, is now known to be a diverse family of protein isoforms generated by complex alternativeExpand
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