Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis*
- T. Tanioka, Yoshihito Nakatani, Natsuki Semmyo, M. Murakami, I. Kudo
- BiologyJournal of Biological Chemistry
- 20 October 2000
The molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE2 biosynthetic pathway, showed similarity to p23, which is reportedly the weakly bound component of the steroid hormone receptor/hsp90 complex.
Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2*
- M. Murakami, H. Naraba, I. Kudo
- Biology, ChemistryJournal of Biological Chemistry
- 20 October 2000
COX-2 and mPGES are essential components for delayed PGE2 biosynthesis, which may be linked to inflammation, fever, osteogenesis, and even cancer.
Phospholipase A2 enzymes.
- I. Kudo, M. Murakami
- BiologyProstaglandins & other lipid mediators
- 1 August 2002
Recent progress in phospholipase A₂ research: from cells to animals to humans.
- M. Murakami, Y. Taketomi, Y. Miki, Hiroyasu Sato, T. Hirabayashi, Kei Yamamoto
- BiologyProgress in lipid research
- 1 April 2011
Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2*
- M. Murakami, K. Nakashima, I. Kudo
- BiologyJournal of Biological Chemistry
- 26 September 2003
Current evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2,…
Prostaglandin E synthase.
- M. Murakami, Yoshihito Nakatani, T. Tanioka, I. Kudo
- BiologyProstaglandins & other lipid mediators
- 1 August 2002
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis.
- I. Kudo, M. Murakami
- BiologyJournal of biochemistry and molecular biology
- 30 November 2005
This review highlights the latest understanding of the expression, regulation and functions of these three PGES enzymes.
Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway.
- M. Murakami, I. Kudo
- BiologyProgress in lipid research
- 2004
Fas-induced Arachidonic Acid Release Is Mediated by Ca2+-independent Phospholipase A2 but Not Cytosolic Phospholipase A2, Which Undergoes Proteolytic Inactivation*
- G. Atsumi, Masae Tajima, Atsuyoshi Hadano, Yoshihito Nakatani, M. Murakami, I. Kudo
- Biology, ChemistryJournal of Biological Chemistry
- 29 May 1998
iPLA2-mediated fatty acid release is facilitated in Fas-stimulated cells and plays a modifying although not essential role in the apoptotic cell death process, concluding that caspase-3-mediated c PLA2 cleavage eventually leads to destruction of a catalytic triad essential for cPLA2 activity, thereby terminating its AA-releasing function.
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