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The genome of the social amoeba Dictyostelium discoideum
TLDR
A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.
Interaction of tyrosine-based sorting signals with clathrin-associated proteins.
TLDR
The medium chains of two clathrin-associated protein complexes specifically interacted with tyrosine-based signals of several integral membrane proteins, and it is likely that the medium chains serve as signal-binding components of the clathin-dependent sorting machinery.
Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.
TLDR
The data support the idea that helix-loop-helix proteins may represent an evolutionarily conserved family of cell-type determination genes, of which MASH1 is the first neural-specific member identified in vertebrates.
Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese.
TLDR
Seven kinds of ripened cheeses were homogenized with distilled water, and water-soluble peptides were prepared by C-18 hydrophobic chromatography, and potent angiotensin I-converting enzyme inhibitory activity with little antihypertensive effects were detected.
Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis.
TLDR
RNA-blot and promoter-beta-glucuronidase (GUS) analysis showed that these GGPP synthases genes are organ-specifically expressed in Arabidopsis, suggesting there will be specific pathways of GGPP production in each organelle.
The Medium Subunits of Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals*
TLDR
All the medium subunits were found to prefer proline at position Y+2, suggesting that YXXØ signals are stabilized by a bend in the polypeptide backbone.
Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor.
TLDR
The results show that HORK3 is a Gi/o-coupled receptor and that its natural ligand is ADP, and support the view that P2Y(1) functions as a high-affinity ADP receptor and P2T(AC) as a low-Affinity ADp receptor in platelets.
Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells.
TLDR
The identification of a novel member of the adaptor medium chain family, named mu1B, which is closely related to the previously described mu1A, and which is capable of interacting with generic tyrosine-based sorting signals suggests that mu1 B may be involved in protein sorting events specific to polarized cells.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion.
TLDR
Chemical synthesis of six peptides confirmed that all peptides, except an undecapeptide, have antihypertensive activity in spontaneously hypertensive rats.
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