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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
The E6 protein encoded by the oncogenic human papillomavirus types 16 and 18 is one of two viral products expressed in HPV-associated cancers. E6 is an oncoprotein which cooperates with E7 to… Expand
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin-activating enzyme (E1),… Expand
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
- Marc G. Wathelet, C. H. Lin, B. S. Parekh, L. Ronco, P. Howley, T. Maniatis
- Biology, Medicine
- Molecular cell
- 1 March 1998
We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon… Expand
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, a neurological… Expand
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.
The E6 protein of human papillomavirus types 16 and 18 (HPV‐16 and HPV‐18) can stably associate with the p53 protein in vitro. In the presence of rabbit reticulocyte lysate, this association leads to… Expand
Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes
The papillomavirus E2 protein tethers viral genomes to host mitotic chromosomes to ensure genome maintenance. We have identified the bromodomain protein Brd4 as a major cellular interacting partner… Expand
The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
ABSTRACT Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and virus-host pathogenesis. To gain mechanistic insight into the various biological functions of Brd4,… Expand
Human papillomavirus immortalization and transformation functions.
The high risk HPVs (such as HPV-16 and HPV-18) that are associated with specific anogenital cancers encode two oncoproteins E6 and E7, which are expressed in the HPV positive cancers. The E7 protein… Expand
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
- J. Huibregtse, M. Scheffner, S. Beaudenon, P. Howley
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 28 March 1995
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53… Expand
Association of human papillomavirus types 16 and 18 E6 proteins with p53.
Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to… Expand