• Publications
  • Influence
Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.
TLDR
The DNA sequences of the coding region, of the 3' untranslated region, and of the sequence block between the "CCAAT" box and "TATA" box in the 5' flanking DNA of the human beta-actin gene are highly homologous to the corresponding sequence of the rat and chicken beta- actin genes. Expand
A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.
TLDR
A huge number of stretches of dT-dG alternating sequence, a sequence that has been shown to adopt the Z-DNA conformation under some conditions, are found in eukaryotic genomes, indicating extraordinary evolutionary conservation. Expand
Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes.
TLDR
Recombinant phages that carry the human smooth muscle (enteric type) gamma-actin gene were isolated from human genomic DNA libraries and amino acid sequence deduced matches those of cDNAs but differs from the protein sequence previously reported at one amino acid position. Expand
Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens.
  • T. Kakunaga
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 March 1978
TLDR
Results suggest that numerous cell divisions were required for the development of the transformation after nitroquinoline oxide treatment of these human cells, and transformed cells showed a higher saturation density and the ability to grow in soft agar, properties that are usually correlated with neoplastic transformation of cells in culture. Expand
Cell variants showing differential susceptibility to ultraviolet light--induced transformation.
TLDR
Six variant clones isolated from a subclone of BALB/3T3-A31 clone showed similar susceptibility to cytotoxic effects induced by ultraviolet light. Expand
Structure and transforming potential of the human cot oncogene encoding a putative protein kinase.
TLDR
The cot oncogene was overexpressed in transformed SHOK cells and found to have a rearranged 3' end in the last coding exon, which probably resulted in a deletion and an altered C' terminus in the transforming protein. Expand
A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB/3T3
  • T. Kakunaga
  • Biology, Medicine
  • International journal of cancer
  • 15 September 1973
TLDR
Transformed cells had a reduced cloning efficiency, and almost the same susceptibility to the cytotoxic effects of carcinogens as untransformed cells, though these properties varied in different lines. Expand
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
TLDR
There is a reasonably good correlation between the results of the cell transformation systems and in vivo carcinogenesis, however, the many deficiencies of the EPA Merged Carcinogen List preclude definitive comparisons. Expand
Molecular structure and evolutionary origin of human cardiac muscle actin gene.
TLDR
Two recombinant phages that contain cardiac muscle actin gene were isolated from a human DNA library and their structures were determined, indicating that they are derived from their ancestor gene at a relatively recent time in evolutionary development. Expand
Potential Z-DNA forming sequences are highly dispersed in the human genome
TLDR
The presence of a sequence of 50 alternating dT and dG residues within one of the introns of a human cardiac muscle actin gene is reported and it is found that potential Z-DNA forming sequences are highly repeated in the human genome. Expand
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