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Nelfinavir

Known as: NFV, Nelfinavir [Chemical/Ingredient] 
A synthetic antiviral agent that selectively binds to and inhibits human immunodeficiency virus (HIV) protease. Nelfinavir has activity against HIV 1… 
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (4)

AG 1343M8-nelfinavirNelfinavir MesylateViracept
Acquired Immunodeficiency SyndromeAstemizoleCYP2C19 protein, humanCYP3A7 protein, human

Broader (4)

Antiviral AgentsHIV Protease InhibitorsIsoquinolinesProtease Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Triple-Antiretroviral Prophylaxis to Prevent Mother-To-Child HIV Transmission through Breastfeeding—The Kisumu Breastfeeding Study, Kenya: A Clinical Trial
Timothy Thomas and colleagues report the results of the Kisumu breastfeeding study (Kenya), a single-arm trial that assessed the… 
Highly Cited
2008
Highly Cited
2008
Lipodystrophy and weight changes: data from the Swiss HIV Cohort Study, 2000–2006
Combination antiretroviral therapy (cART) is changing, and this may affect the type and occurrence of side effects. We examined… 
Highly Cited
2005
Highly Cited
2005
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo
Objectives The human immunodeficiency virus protease inhibitor nelfinavir is substrate of polyspecific drug transporters encoded… 
Highly Cited
2005
Highly Cited
2005
Determination of antiretroviral agents in human serum by capillary electrophoresis.
Highly Cited
2004
Highly Cited
2004
Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes.
Highly Cited
2004
Highly Cited
2004
Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA.
In the course of studying the incidence of k- ras mutations in DNA in the circulation of patients with colorectal disease, we… 
Highly Cited
2003
Highly Cited
2003
Treatment Failure of Nelfinavir-Containing Triple Therapy Can Largely Be Explained by Low Nelfinavir Plasma Concentrations
The relationship between plasma concentrations of nelfinavir and virologic treatment failure was investigated to determine the… 
Highly Cited
2003
Highly Cited
2003
Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography.
Highly Cited
2001
Highly Cited
2001
Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients
ObjectiveTo characterize sources of variation in plasma concentrations of nelfinavir and its active metabolite M8 and to evaluate… 
Highly Cited
1999
Highly Cited
1999
Virologic responses to a ritonavir--saquinavir-containing regimen in patients who had previously failed nelfinavir.
OBJECTIVES The effectiveness of a second protease inhibitor in patients who failed an initial protease inhibitor is unclear but… 
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