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Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis
A method for the rapid identification of mycobacteria to the species level was developed on the basis of evaluation by the polymerase chain reaction (PCR) of the gene encoding for the 65-kDa protein.
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
TLDR
Several monoclonal antibodies that target the S glycoprotein of SARS-CoV-2, which was identified from memory B cells of an individual who was infected with severe acute respiratory syndrome coronavirus (SARS- coV) in 2003, and one antibody (named S309) potently neutralization, which may limit the emergence of neutralization-escape mutants.
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
TLDR
Using a whole-genome association strategy, polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection are identified.
Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
TLDR
Treatment failure and CNS side-effects are associated with low and high efavirenz plasma levels, respectively, which strongly argues for dose adjustment on the basis of therapeutic drug monitoring to optimize treatment.
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.
TLDR
The association of the IL28B locus with natural and treatment-associated control of HCV indicates the importance of innate immunity and interferon lambda in the pathogenesis ofHCV infection.
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
TLDR
The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.
Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel.
TLDR
This report provides guidelines for when to initiate antiretroviral therapy, selection of appropriate initial regimens, patient monitoring, when to change therapy, and what regimens to use when changing.
A novel insertion element from Mycobacterium avium, IS1245, is a specific target for analysis of strain relatedness
The insertion sequence IS1245 is a novel mycobacterial repetitive element identified in Mycobacterium avium. It encodes a transposase which exhibits a 64% amino acid similarity with IS1081, an
Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level
TLDR
Molecular detection of resistance to the two main antituberculous drugs, INH and RMP, can be accomplished accurately by using a strategy which limits analysis to four genetic regions, which may allow the expedient analysis of drug resistance by reference laboratories.
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