All Fields
Computer Science
Medicine
FAQ
Contact
Sign in
Isoquinolines
Known as:
2 benzazine
, Isoquinolines [Chemical/Ingredient]
, isoquinoline
Â
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids…Â
(More)
National Institutes of Health
Topic mentions per year
Topic mentions per year
1946-2017
0
50
100
1946
2016
Related topics
Related topics
50 relations
Narrower (48)
1-hydroxymethyl-7-methoxyisoquinolin-6-ol
3-acetylisoquinoline
A-1331852
AR-12286
(More)
Acetaldehyde
antagonists & inhibitors
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
Isoquinolines
Acetaldehyde
alrestatin
lucifer yellow
oracine
saquinavir mesylate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Pravinkumar Satyanarayan Bhutada
,
Yogita R Mundhada
,
Kuldeep U Bansod
,
Pankaj V Dixit
,
Sudhir Niranjan Umathe
,
Dharmendra R. Mundhada
Epilepsy & behavior : E&B
2010
Berberine, an isoquinoline alkaloid is reported to modulate several neurotransmitter systems like N-methyl-D-aspartate, nitric…Â
(More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Neuroinflammation in schizophrenia-related psychosis: a PET study.
Janine Doorduin
,
Erik F. J. de Vries
,
Antoon T. M. Willemsen
,
Jan Cees de Groot
,
Rudi A. Dierckx
,
Hans C. Klein
Journal of nuclear medicine : official…
2009
UNLABELLED Schizophrenia is a chronic and disabling brain disease characterized by psychotic episodes with unknown etiology. It…Â
(More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.
Esra Küpeli
,
Müberra Koşar
,
Erdem YeÅŸilada
,
K Hüsnü
,
Canan A Baser
Life sciences
2002
Roots and barks of various Berberis species are used as folk remedy for the treatment of various inflammatory diseases such as…Â
(More)
Is this relevant?
2002
2002
Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter.
Alexander Storch
,
Stefanie Ott
,
+7 authors
Johannes Schwarz
Biochemical pharmacology
2002
Endogenous isoquinoline (IQ) derivatives structurally related to the selective dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6…Â
(More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues.
Benjamin D. Humphreys
,
Caterina Virginio
,
Annmarie Surprenant
,
J. Rice
,
George R Dubyak
Molecular pharmacology
1998
1-[N, O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) and N-[1-[N-methyl-p-(5 isoquinolinesulfonyl…Â
(More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
Caroline E Gargett
,
Joshua S Wiley
British journal of pharmacology
1997
1. Extracellular adenosine 5'-triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of…Â
(More)
Is this relevant?
1995
1995
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Kevin St. P. McNaught
,
Ulrike Thull
,
+6 authors
Clare D. Marsden
Biochemical pharmacology
1995
Mitochondrial respiratory failure secondary to complex I inhibition may contribute to the neurodegenerative process underlying…Â
(More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.
Maureen W. McEnery
,
Adele M. Snowman
,
Rosario Rich Trifiletti
,
S. H. Snyder
Proceedings of the National Academy of Sciences…
1992
The mitochondrial benzodiazepine receptor (mBzR) has been solubilized with retention of reversible ligand binding, and the…Â
(More)
Is this relevant?
1990
1990
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.
Michael E Bembenek
,
Chris Abell
,
Linda Chrisey
,
Maria D Rozwadowska
,
Wolfgang Gessner
,
Adriana Bortoleto Brossi
Journal of medicinal chemistry
1990
A series of 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines were tested as substrates and/or inactivators of…Â
(More)
Is this relevant?
Highly Cited
1984
Highly Cited
1984
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
H. Hidaka
,
M. Inagaki
,
S. Kawamoto
,
Y. Sasaki
Biochemistry
1984
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists…Â
(More)
Is this relevant?