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Isoquinolines

Known as: 2 benzazine, Isoquinolines [Chemical/Ingredient], isoquinoline 
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
05010019462016

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50 relations

Narrower (48)

1-hydroxymethyl-7-methoxyisoquinolin-6-ol3-acetylisoquinolineA-1331852AR-12286
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Acetaldehydeantagonists & inhibitors

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Isoquinolines
Acetaldehyde
alrestatin
lucifer yellow
oracine
saquinavir mesylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Berberine, an isoquinoline alkaloid is reported to modulate several neurotransmitter systems like N-methyl-D-aspartate, nitric… (More)
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Highly Cited
2009
Highly Cited
2009
Neuroinflammation in schizophrenia-related psychosis: a PET study.
UNLABELLED Schizophrenia is a chronic and disabling brain disease characterized by psychotic episodes with unknown etiology. It… (More)
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Highly Cited
2002
Highly Cited
2002
A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.
Roots and barks of various Berberis species are used as folk remedy for the treatment of various inflammatory diseases such as… (More)
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2002
2002
Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter.
Endogenous isoquinoline (IQ) derivatives structurally related to the selective dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6… (More)
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Highly Cited
1998
Highly Cited
1998
Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues.
1-[N, O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) and N-[1-[N-methyl-p-(5 isoquinolinesulfonyl… (More)
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Highly Cited
1997
Highly Cited
1997
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
1. Extracellular adenosine 5'-triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of… (More)
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1995
1995
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Mitochondrial respiratory failure secondary to complex I inhibition may contribute to the neurodegenerative process underlying… (More)
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Highly Cited
1992
Highly Cited
1992
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.
The mitochondrial benzodiazepine receptor (mBzR) has been solubilized with retention of reversible ligand binding, and the… (More)
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1990
1990
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines.
A series of 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines were tested as substrates and/or inactivators of… (More)
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Highly Cited
1984
Highly Cited
1984
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists… (More)
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