Skip to search formSkip to main contentSkip to account menu

Almorexant

Known as: ((2R)-2-((1S)-6,7-dimethoxy-1-(2-(4-trifluoromethylphenyl)-ethyl)-3,4-dihydro-1H-isoquinolin-2-yl)-N-methyl-2-phenylacetamide), (2R)-2-((1S)-6,7-Dimethoxy-1-(2-(4-(Trifluoromethyl)Phenyl)Ethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-N-Methyl-2-Phenylacetamide 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

ACT-078573

Broader (2)

AcetamidesIsoquinolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Both Ox1r and Ox2r orexin receptors contribute to the cardiovascular and locomotor components of the novelty stress response in the rat
2013
2013
Examining the role of endogenous orexins in hypothalamus–pituitary–adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat
Highly Cited
2012
Highly Cited
2012
Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1… 
Highly Cited
2012
Highly Cited
2012
Orexin receptor antagonism: an ascending multiple-dose study with almorexant
The objectives of this study were to investigate the multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics… 
2012
2012
Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses.
Orexin neurons form a restricted group in the dorsal hypothalamus. The group is centered on the perifornical area within the… 
Highly Cited
2012
Highly Cited
2012
Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression
Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in the pathophysiology of major… 
2011
2011
Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat
Current insomnia treatments such as γ-aminobutyric acid (GABA) receptor modulators are associated with sedative and muscle… 
Highly Cited
2010
Highly Cited
2010
Orexin Receptor Antagonism, a New Sleep‐Promoting Paradigm: An Ascending Single‐Dose Study With Almorexant
Almorexant, a dual orexin receptor antagonist potentially representing a new class of sleep‐promoting compounds, was administered… 
Highly Cited
2010
Highly Cited
2010
Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant
RationaleOrexins play a key role in the maintenance of alertness and are implicated in the modulation of diverse physiological… 
Highly Cited
2009
Highly Cited
2009
Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists
Recent preclinical and clinical research has shown that almorexant promotes sleep in animals and humans without disrupting the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)