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Almorexant

Known as: ((2R)-2-((1S)-6,7-dimethoxy-1-(2-(4-trifluoromethylphenyl)-ethyl)-3,4-dihydro-1H-isoquinolin-2-yl)-N-methyl-2-phenylacetamide), (2R)-2-((1S)-6,7-Dimethoxy-1-(2-(4-(Trifluoromethyl)Phenyl)Ethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-N-Methyl-2-Phenylacetamide 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

ACT-078573

Broader (2)

AcetamidesIsoquinolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Almorexant: A new Promising Molecule in the Treatment of Digestive Cancers
2016
2016
Dual orexin receptor antagonist, almorexant, in elderly patients with primary insomnia: a randomized, controlled study.
OBJECTIVE Sleep laboratory study to determine the dose-related efficacy and safety of almorexant in elderly patients with primary… 
2015
2015
Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway
2014
2014
Entry‐into‐humans study with ACT‐462206, a novel dual orexin receptor antagonist, comparing its pharmacodynamics with almorexant
A double‐blind, placebo‐ and active comparator‐controlled, randomized, single‐ascending‐dose study was conducted to investigate… 
2013
2013
Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
2013
2013
Enantioselective synthesis of almorexant via iridium-catalysed intramolecular allylic amidation.
An enantioselective synthesis of almorexant, a potent antagonist of human orexin receptors, is presented. The chiral… 
2013
2013
Influence of mild and moderate liver impairment on the pharmacokinetics and metabolism of almorexant, a dual orexin receptor antagonist.
2013
2013
Treating hypertension by targeting orexin receptors: potential effects on the sleep‐related blood pressure dipping profile
We read with interest the recent paper by Li et al. (2013) concerning the cardiovascular effects of the dual orexin receptor… 
2012
2012
The brain orexin system and almorexant in fear-conditioned startle reactions in the rat
The rat fear-potentiated startle (FPS) paradigm is a translational model of conditioned fear involving central amygdala pathways… 
2011
2011
Pharmacokinetics and Tolerability of Almorexant in Japanese and Caucasian Healthy Male Subjects
Background/Aims: The aim of this study was to compare the pharmacokinetics and tolerability of single doses of the dual orexin… 
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