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Cognitive performance and serotonergic function in users of ecstasy
Evidence is provided that use of ecstasy may be associated with impairment of memory and of serotonergic function, compatible with neurotoxicity of ecstasy as shown in animals.
Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
MDMA induces oxytocin release in humans, which may be involved in the characteristic prosocial effects of ecstasy, in a double blind, randomized, crossover, and placebo-controlled study in 15 healthy volunteers.
Subjective Sleep Disturbance in Patients with Partial Epilepsy: A Questionnaire‐based Study on Prevalence and Impact on Quality of Life
Summary: Purpose: This study was designed to assess whether sleep disturbance is more frequent among patients with partial seizures and what impact on quality of life (QoL) sleep disturbance may…
Dopamine-dependent architecture of cortico-subcortical network connectivity.
Using a combination of functional neuroimaging and pharmacological challenges in healthy volunteers, opposing dopamine agonistic and antagonistic neuromodulatory effects on distributed functional interactions between specific subcortical regions and corresponding neocortical "resting-state" networks are identified.
Biomarkers for the effects of cannabis and THC in healthy volunteers.
- L. Zuurman, Annelies E Ippel, Eduard Moin, J. V. van Gerven
- BiologyBritish journal of clinical pharmacology
An increasing number of novel therapeutic agents are targeted at cannabinoid receptors. Drug development programmes of new cannabinoid drugs may be facilitated by the identification of useful…
Effects of morphine and alcohol on functional brain connectivity during “resting state”:A placebo‐controlled crossover study in healthy young men
This double blind placebo‐controlled (double dummy) crossover study aimed to investigate whether different psychoactive substances cause drug‐specific effects in functional brain connectivity during resting‐state, revealing dissociable changes in both pharmacodynamics and functional connectivity resulting from alcohol and morphine.
Placebo-Controlled Comparison of Three Dose-Regimens of 5-Hydroxytryptophan Challenge Test in Healthy Volunteers
- H. Gijsman, J. V. van Gerven, A. Cohen
- Medicine, BiologyJournal of clinical psychopharmacology
- 1 April 2002
The authors conclude that this regimen of 5-HTP 100 mg plus carbidopa is a relatively simple, effective, and tolerable challenge of the presynaptic serotonergic system.
Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers
Co-administration of MDMA and ethanol did not exacerbate the effects of either drug alone, and impaired memory function was consistently observed after all drug conditions, whereas impairment of psychomotor function and attention was less consistent across drug conditions.
Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol.
- A. Hazekamp, R. Ruhaak, L. Zuurman, J. V. van Gerven, R. Verpoorte
- MedicineJournal of pharmaceutical sciences
- 1 June 2006
Evaluating the performance of the Volcano vaporizer in terms of reproducible delivery of the bioactive cannabinoid tetrahydrocannabinol (THC) by using pure cannabinoid preparations, shows that with the Volcano a safe and effective cannabinoid delivery system seems to be available to patients.
Effect of Subanesthetic Ketamine on Intrinsic Functional Brain Connectivity: A Placebo-controlled Functional Magnetic Resonance Imaging Study in Healthy Male Volunteers
Changes in connectivity were observed in the areas that explain ketamine's pharmacodynamic profile with respect to analgesia and psychedelic and other side effects, and pain and ketamine changed brain connectivity in areas involved in endogenous pain modulation.