The brain orexin system and almorexant in fear-conditioned startle reactions in the rat

@article{Steiner2012TheBO,
  title={The brain orexin system and almorexant in fear-conditioned startle reactions in the rat},
  author={Michel Alexander Steiner and Hugues Lecourt and François Jenck},
  journal={Psychopharmacology},
  year={2012},
  volume={223},
  pages={465-475}
}
The rat fear-potentiated startle (FPS) paradigm is a translational model of conditioned fear involving central amygdala pathways of the brain. Hypothalamic orexin neurons have input–output projections to the amygdala; they modulate vigilance and stress-related responses. To investigate whether the transient pharmacological blockade of orexin receptors moderates the conditioned fear response. F344 rats received acute oral treatment with the dual orexin receptor antagonist almorexant (30–300 mg… CONTINUE READING