• Publications
  • Influence
Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity. Expand
Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat
  • S. Pellow, S. File
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
  • 1 March 1986
The current studies further investigated the effects, in animal models of anxiety, of novel putative anxiolytic and anxiogenic compounds believed to induce their effects by actions at the GABA-benzodiazepine receptor complex to provide further validation for a novel test of anxiety based on the ratio of open to closed arm entries in an elevated plus maze in the rat. Expand
Effects of moderate alcohol consumption on the central nervous system.
The cognitive effects of acute and chronic moderate intake of ethanol is reviewed, and although a number of studies have noted a measurable diminution in neuropsychologic parameters in habitual consumers of moderate amounts of ethanol, others have not found such changes. Expand
A review of 25 years of the social interaction test.
  • S. File, P. Seth
  • Psychology, Medicine
  • European journal of pharmacology
  • 28 February 2003
The social interaction test of anxiety was developed 25 years ago to provide an ethologically based test that was sensitive to both anxiolytic and anxiogenic effects and has played a crucial role in unravelling the neural basis of anxiety. Expand
The influence of open arm ledges and maze experience in the elevated plus-maze
It is suggested that both types of plus-maze may be measuring the same type of anxiety with different sensitivities on trial 1 (e.g., generalised anxiety or fear of open spaces); different types of anxiety on trial 2 (without ledges)--phobia/fear of heights; with ledges--not known), and trial 3 in the maze with ledge, yet another type of Anxiety. Expand
Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus.
The results show that the dorsal hippocampus is one area that can mediate anxiogenic effects in the social interaction test, but the brain region mediating anxiolytic effects remains to be identified. Expand
The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs
  • S. File
  • Medicine, Psychology
  • Journal of Neuroscience Methods
  • 1 June 1980
The social interaction test in rats provides a method for detecting anxiolytic activity that does not use food or water deprivation, or electric shock, and therefore obviates difficulties ofExpand
Endocannabinoid system and stress and anxiety responses
The endocannabinoid system appears to play a pivotal role in the regulation of emotional states and may constitute a novel pharmacological target for anti-anxiety therapy. Expand
  • S. File, J. Hyde
  • Psychology, Medicine
  • British journal of pharmacology
  • 1 January 1978
Chlordiazepoxide (5 mg/kg) given chronically prevented or significantly reduced the decrease in social interaction that occurred in undrugged rats as the light level or the unfamiliarity of the test box was increased. Expand
Comparative Study of Pre- and Postsynaptic 5-HT1AReceptor Modulation of Anxiety in Two Ethological Animal Tests
Evidence is provided that stimulation of the presynaptic 5-HT1A receptors in the median raphénucleus results in an anxiolytic action, whereas stimulation of those of the post-synaptic 4- HT1Areceptors in its projection area of the dorsal hippocampus results in a anxiogenic effect. Expand