Y. Akao

Publications321
h-index64
Citations14,007
Highly Influential Citations404
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Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells.
let-7 microRNA functions as a potential growth suppressor in human colon cancer cells.
TLDR
The expression of let-7 miRNAs in human colon cancer tumors and cell lines is examined, with the result that 2 of 6 cases and 1 of 3 cell lines showed reduced expression ofLet-7.
Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.
TLDR
The use of biochemical fractionation, immunofluorescence laser-scanning confocal microscopy, and immunoelectron microscopy with mouse anti-human bcl-2 monoclonal antibody revealed the protein prominently in the nuclear envelope, endoplasmic reticulum membrane, and mitochondrial membranes, suggesting an important role for this protein in several different membrane compartments.
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.
Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
TLDR
A mechanism of α-mangostin-induced growth inhibition in DLD-1 cells is focused on, which could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers.
TLDR
Findings indicate that the miRNAs 143 and 145 could become good tumor markers and provide an important clue in the study of the mechanism of oncogenesis involving miRN as well as other kinds of cancer cells tested.
MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5
TLDR
It is observed for the first time that miR-141 and -200a are involved in pre-osteoblast differentiation in part by regulating the expression of Dlx5.
Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro
Downregulation of microRNAs‐143 and ‐145 in B‐cell malignancies
TLDR
It is demonstrated that the expression of miRNAs ‐143 and ‐145, the levels of which were previously shown to be reduced in colon cancers and various kinds of established cancer cell lines, was also decreased in most of the B‐cell malignancies examined, including chronic lymphocytic leukemias and Burkitt lymphoma cell lines.
MicroRNA-143 and -145 in colon cancer.
TLDR
The expression of miRNA-143 and -145 in colon cancer and their roles in carcinogenesis are discussed, and the available data suggest that miRNAs would be potentially useful as diagnostic and therapeutic tools.
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