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Ligustrazine, a compound extracted from roots of Ligusticum chuanxiong, is widely used in Chinese traditional medicine to treat… Expand Pin1 is closely associated with the pathogenesis of cancers and Alzheimer's disease (AD). Previously, we have shown the… Expand Repeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The… Expand Previously we demonstrated that chronic hypoxia (CH) induces an inflammatory condition characterized by immune cell invasion and… Expand UNLABELLED
Acid-sensing ion channels (ASICs) respond to acidosis that normally occurs after inflammation. We examined the… Expand The synthesis, structure-activity relationship (SAR), and pharmacological evaluation of analogs of the acid-sensing ion channel… Expand The exercise pressor reflex is evoked by both mechanical and metabolic stimuli arising in contracting skeletal muscle. Recently… Expand RationaleAcid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems… Expand The exercise pressor reflex arises from contracting skeletal muscle and is believed to play a role in evoking the cardiovascular… Expand &NA; Acid Sensing Ion Channels (ASICs) are a group of sodium‐selective ion channels that are activated by low extracellular pH… Expand