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Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.
Uncoupling protein 2 (UCP2) negatively regulates insulin secretion. UCP2 deficiency (by means of gene knockout) improves obesity- and high glucose-induced beta cell dysfunction and consequently… Expand
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis… Expand
Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol
- R. Cencic, M. Carrier, +9 authors J. Pelletier
- Medicine, Chemistry
- PloS one
- 29 April 2009
Background Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to… Expand
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
- S. Santagata, M. Mendillo, +12 authors S. Lindquist
- Biology, Medicine
- Science
- 19 July 2013
Introduction Ribosome biogenesis is commonly up-regulated to satisfy the increased anabolic demands associated with malignant transformation and tumor growth. Many different oncogenic signaling… Expand
nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.
- V. Gandin, Laia Masvidal, +14 authors I. Topisirovic
- Biology, Medicine
- Genome research
- 16 March 2016
The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation of the TOP (terminal oligopyrimidine… Expand
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
- M. Bordeleau, F. Robert, +8 authors J. Pelletier
- Medicine, Biology
- The Journal of clinical investigation
- 1 July 2008
Disablement of cell death programs in cancer cells contributes to drug resistance and in some cases has been associated with altered translational control. As eukaryotic translation initiation factor… Expand
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
- Nava Zaarur, V. Gabai, J. Porco, S. Calderwood, M. Sherman
- Biology, Medicine
- Cancer research
- 1 February 2006
Novel classes of anticancer drugs, including proteasome inhibitors and Hsp90 inhibitors, potently induce heat shock proteins (Hsps). Because Hsps show antiapoptotic activities, we suggested that… Expand
Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.
- M. Liang, S. Bardhan, +4 authors T. Gilmore
- Biology, Medicine
- Biochemical pharmacology
- 28 February 2006
Transcription factor NF-kappaB is constitutively active in many human chronic inflammatory diseases and cancers. Epoxyquinone A monomer (EqM), a synthetic derivative of the natural product… Expand
Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities
Abstract Pestalotiopsis microspora, an endophytic fungus native to the rainforest of Papua New Guinea, produces a 1,3-dihydro isobenzofuran. This product, pestacin, is 1,5,7-trisubstituted and… Expand
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma
- J. Schatz, E. Oricchio, +13 authors H. Wendel
- Biology, Medicine
- The Journal of experimental medicine
- 29 August 2011
PIM kinase expression in human lymphomas can influence the outcome of chemotherapy, and blocking cap-dependent translation can reverse PIM-mediated rapamycin resistance in murine lymphomas.
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