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Sociodemographic and psychological variables influencing adherence to antiretroviral therapy.
Overall, IVDUs and younger individuals tend to have a poorer compliance, as well as subjects with depression and lack of self-perceived social support, which should indirectly improve the effectiveness of antiretroviral therapy.
Selection of Hepatitis B Virus Polymerase Mutations in HIV-Coinfected Patients Treated with Tenofovir
The selection of HBV mutations in HBV/HIV-coinfected patients failing TDF therapy is an unlikely event within the first 12 months of treatment, however, HBV from two of the 43 patients treated with TDF for more than 12 months was found to contain one novel mutation located distal to the catalytic site of the HBV pol.
Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management.
BACKGROUND Infection with drug-resistant human immunodeficiency virus type 1 (HIV-1) can impair the response to combination therapy. Widespread transmission of drug-resistant variants has the
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel.
There are several reasons to highlight HBV in HIV positive individuals, and a few reports have devoted particular attention to hepatitis B, which is currently an important cause of morbidity and mortality among HIV-infected patients in the western world.
Combination Therapy With Telaprevir for Chronic Hepatitis C Virus Genotype 1 Infection in Patients With HIV
In patients withHCV and HIV-1, more adverse events occurred with TVR versus placebo plus PEG-IFN-α2a-ribavirin; these were similar in nature and severity to those in patients with HCV treated with TV R.
Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel.
Eleven areas have been identified in which new recommendations are particu-larly needed: management of patients with persistently normalaminotransferasesliverrosis assessment: when and how predictors of response to anti-HCV therapy in coinfected patients, and interactions between HCV medications and antiretroviraldrugs.
HIV entry inhibitors: mechanisms of action and resistance pathways.
Entry inhibitors represent a new generation of antivirals for the treatment of HIV infection which block the attachment of HIV gp120 to either the CD4 T cell receptor or the CCR5/CXCR4 co-receptors.
Care of patients with hepatitis C and HIV co-infection.
A final consensus was reached in a second meeting of experts in the field of HIV and viral hepatitis in the setting of HIV infection held in Barcelona in the summer of 2002, and is presented here.
Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy.
HCV serostatus did not affect the risk of HIV-1 disease progression, but therisk of liver disease-related deaths was markedly increased in HCV-seropositive patients.
Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.
This study explored the association between kidney tubular dysfunction (KTD) and polymorphisms in genes encoding drug transporters in HIV-infected patients receiving tenofovir-containing antiretroviral regimens and found homozygosity for the C allele at position -24 of the ABCC2 gene was strongly associated with KTD in this population.