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Protease Inhibitors

Known as: Peptide Hydrolase Inhibitors, Inhibitors, Peptidase, Inhibitors, Peptide Peptidohydrolase 
A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies… Expand
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (39)

1,6-bis(cyclohexyloximinocarbonyl)hexane2-mercaptomethyl-3-guanidinoethylthiopropionic acid4-hydroxymercuribenzoate4-toluenesulfonyl fluoride
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Broader (1)

Enzyme Inhibitors
In BloodPI15 genePI16 genePI3 gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Function and mechanisms of enteroendocrine cells and gut hormones in metabolism
Gut hormones have many key roles in the control of metabolism, as they target diverse tissues involved in the control of… Expand
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Highly Cited
2003
Highly Cited
2003
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected… Expand
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Highly Cited
2001
Highly Cited
2001
A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
Nonadherence to medication is a major obstacle to successful medical treatment. Despite the efforts of providers, pharmaceutical… Expand
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Highly Cited
2000
Highly Cited
2000
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
ObjectiveTo examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless… Expand
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Highly Cited
2000
Highly Cited
2000
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas. In approximately one-third of all… Expand
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Highly Cited
1999
Highly Cited
1999
Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: acohort study
BACKGROUND The prevalence and severity of lipodystrophy syndrome with long-term therapy for HIV-1 infection that includes a… Expand
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Highly Cited
1998
Highly Cited
1998
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
Objective:To describe a syndrome of peripheral lipodystrophy (fat wasting of the face, limbs and upper trunk), hyperlipidaemia… Expand
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Highly Cited
1998
Highly Cited
1998
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
BACKGROUND AND METHODS National surveillance data show recent, marked reductions in morbidity and mortality associated with the… Expand
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Highly Cited
1998
Highly Cited
1998
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral… Expand
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Highly Cited
1995
Highly Cited
1995
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
INHIBITORS of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic… Expand
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