Protease Inhibitors

Known as: Peptide Hydrolase Inhibitors, Inhibitors, Peptidase, Inhibitors, Peptide Peptidohydrolase 
A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
BACKGROUND & AIMS Hepatitis C virus (HCV) therapy that is highly efficacious, pangenotypic, with a high barrier to resistance and… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Peginterferon plus ribavirin achieves sustained virological response (SVR) in fewer than half of patients with… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS Telaprevir (VX-950), a hepatitis C virus (HCV) NS3.4A protease inhibitor, has shown strong antiviral activity… (More)
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Highly Cited
2001
Highly Cited
2001
Nonadherence to medication is a major obstacle to successful medical treatment. Despite the efforts of providers, pharmaceutical… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The prevalence and severity of lipodystrophy syndrome with long-term therapy for HIV-1 infection that includes a… (More)
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Highly Cited
1999
Highly Cited
1999
Programmed cell death (PCD) is a process by which cells in many organisms die. The basic morphological and biochemical features… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE To describe a syndrome of peripheral lipodystrophy (fat wasting of the face, limbs and upper trunk), hyperlipidaemia… (More)
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Highly Cited
1998
Highly Cited
1998
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral… (More)
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Highly Cited
1995
Highly Cited
1995
INHIBITORS of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic… (More)
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