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Protease Inhibitors

Known as: Peptide Hydrolase Inhibitors, Inhibitors, Peptidase, Inhibitors, Peptide Peptidohydrolase 
A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (39)

1,6-bis(cyclohexyloximinocarbonyl)hexane2-mercaptomethyl-3-guanidinoethylthiopropionic acid4-hydroxymercuribenzoate4-toluenesulfonyl fluoride

Broader (1)

Enzyme Inhibitors
In BloodPI15 genePI16 genePI3 gene

Papers overview

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Highly Cited
2006
Highly Cited
2006
Treatment for Adult HIV Infection 2006 Recommendations of the International AIDS Society–USA Panel
THE YEAR 2006 MARKS THE 25TH anniversary of the initial clinical descriptions of what would be later termed the acquired… 
Highly Cited
2003
Highly Cited
2003
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected… 
Highly Cited
2000
Highly Cited
2000
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
We describe here eleven different mutations in SPINK5, encoding the serine protease inhibitor LEKTI, in 13 families with… 
Highly Cited
1998
Highly Cited
1998
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral… 
Highly Cited
1996
Highly Cited
1996
Ethylene as a Signal Mediating the Wound Response of Tomato Plants
Plants respond to physical injury, such as that caused by foraging insects, by synthesizing proteins that function in general… 
Highly Cited
1996
Highly Cited
1996
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
Analysis of the HIV protease gene from the plasma of HIV–infected patients revealed substitutions at nine different codons… 
Highly Cited
1995
Highly Cited
1995
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
INHIBITORS of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic… 
Highly Cited
1990
Highly Cited
1990
Interplant communication: airborne methyl jasmonate induces synthesis of proteinase inhibitors in plant leaves.
Inducible defensive responses in plants are known to be activated locally and systemically by signaling molecules that are… 
Highly Cited
1988
Highly Cited
1988
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits… 
Highly Cited
1981
Highly Cited
1981
Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.
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