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Protease Inhibitors

Known as: Peptide Hydrolase Inhibitors, Inhibitors, Peptidase, Inhibitors, Peptide Peptidohydrolase 
A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (39)

1,6-bis(cyclohexyloximinocarbonyl)hexane2-mercaptomethyl-3-guanidinoethylthiopropionic acid4-hydroxymercuribenzoate4-toluenesulfonyl fluoride

Broader (1)

Enzyme Inhibitors
In BloodPI15 genePI16 genePI3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected… 
Highly Cited
2001
Highly Cited
2001
A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
Nonadherence to medication is a major obstacle to successful medical treatment. Despite the efforts of providers, pharmaceutical… 
Review
2000
Review
2000
Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
Improved therapeutic strategies, including the introduction of protease inhibitors, have led to a striking decrease in HIV… 
Highly Cited
2000
Highly Cited
2000
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
ObjectiveTo examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless… 
Highly Cited
2000
Highly Cited
2000
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas. In approximately one-third of all… 
Highly Cited
2000
Highly Cited
2000
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
We describe here eleven different mutations in SPINK5, encoding the serine protease inhibitor LEKTI, in 13 families with… 
Highly Cited
1999
Highly Cited
1999
The Involvement of Cysteine Proteases and Protease Inhibitor Genes in the Regulation of Programmed Cell Death in Plants
Programmed cell death (PCD) is a process by which cells in many organisms die. The basic morphological and biochemical features… 
Highly Cited
1998
Highly Cited
1998
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
Objective:To describe a syndrome of peripheral lipodystrophy (fat wasting of the face, limbs and upper trunk), hyperlipidaemia… 
Highly Cited
1998
Highly Cited
1998
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
BACKGROUND AND METHODS National surveillance data show recent, marked reductions in morbidity and mortality associated with the… 
Highly Cited
1998
Highly Cited
1998
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral… 
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