Protease Inhibitors

Known as: Peptide Hydrolase Inhibitors, Inhibitors, Peptidase, Inhibitors, Peptide Peptidohydrolase 
A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies… (More)
National Institutes of Health

Related topics

Related topics

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Narrower (40)

1,6-bis(cyclohexyloximinocarbonyl)hexane2-mercaptomethyl-3-guanidinoethylthiopropionic acid4-hydroxymercuribenzoate4-toluenesulfonyl fluoride
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Broader (1)

Enzyme Inhibitors
In BloodPI15 genePI16 genePI3 gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis.
BACKGROUND & AIMS Hepatitis C virus (HCV) therapy that is highly efficacious, pangenotypic, with a high barrier to resistance and… (More)
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Highly Cited
2010
Highly Cited
2010
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label…
BACKGROUND Peginterferon plus ribavirin achieves sustained virological response (SVR) in fewer than half of patients with… (More)
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Highly Cited
2007
Highly Cited
2007
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir.
BACKGROUND & AIMS Telaprevir (VX-950), a hepatitis C virus (HCV) NS3.4A protease inhibitor, has shown strong antiviral activity… (More)
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Highly Cited
2001
Highly Cited
2001
A comparison study of multiple measures of adherence to HIV protease inhibitors.
Nonadherence to medication is a major obstacle to successful medical treatment. Despite the efforts of providers, pharmaceutical… (More)
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Highly Cited
2000
Highly Cited
2000
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population.
OBJECTIVE To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless… (More)
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Highly Cited
1999
Highly Cited
1999
Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: acohort study
BACKGROUND The prevalence and severity of lipodystrophy syndrome with long-term therapy for HIV-1 infection that includes a… (More)
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Highly Cited
1999
Highly Cited
1999
The involvement of cysteine proteases and protease inhibitor genes in the regulation of programmed cell death in plants.
Programmed cell death (PCD) is a process by which cells in many organisms die. The basic morphological and biochemical features… (More)
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Highly Cited
1998
Highly Cited
1998
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors.
OBJECTIVE To describe a syndrome of peripheral lipodystrophy (fat wasting of the face, limbs and upper trunk), hyperlipidaemia… (More)
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Highly Cited
1998
Highly Cited
1998
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral… (More)
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Highly Cited
1995
Highly Cited
1995
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
INHIBITORS of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic… (More)
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