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Selection of Antiepileptic Drug Polytherapy Based on Mechanisms of Action: The Evidence Reviewed
Summary: Purpose: When monotherapy with antiepileptic drugs (AEDs) fails, combination therapy is tried in an attempt to improve effectiveness by improving efficacy, tolerability, or both. We reviewedExpand
Reappraisal of Polytherapy in Epilepsy: A Critical Review of Drug Load and Adverse Effects
Whether an analysis of published data could clarify the relationship between antiepileptic drug (AED) polytherapy and adverse affects (AE) and problems encountered is reviewed. Expand
Adherence Rates and Associations with Nonadherence in Patients with Rheumatoid Arthritis Using Disease Modifying Antirheumatic Drugs
In this large study with a random RA population, 32%–40% of the patients did not adhere to their DMARD prescription, and no general risk factor seems to be powerful enough as a possible screening tool or target for adherence-improving interventions. Expand
Pharmacovigilance in Perspective
Pharmacovigilance plays a major role in pharmacotherapeutic decision-making, be it individual, regional, national or international, and is becoming a scientific discipline in its own right. Expand
Clinical pharmacokinetics of sulfonamides and their metabolites: an encyclopedia.
Pharmacokinetics of Adjusted-Dose Lopinavir-Ritonavir Combined with Rifampin in Healthy Volunteers
Adjusted-dose regimens of lopinavir-ritonavir in combination with therapeutic drug monitoring and monitoring of liver function may allow concomitant use of rifampin. Expand
Evaluation of antiretroviral drug measurements by an interlaboratory quality control program.
The program revealed a large variability in the laboratories' ability to measure antiretroviral drugs accurately, which may have important implications for therapeutic drug monitoring of these drugs and for pharmacokinetic studies. Expand
Application of the ATC/DDD methodology to monitor antibiotic drug use
The Anatomical Therapeutical Chemical Classification/Defined Daily Doses (ATC/DDD) system developed by the World Health Organisation was evaluated, which measures the amount of drug use independent of package size and sales price, which allows comparisons not only within an institution but also within a region, a country, or even internationally. Expand
Effect of low‐dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers
In the treatment of human immunodeficiency virus infection, the protease inhibitor ritonavir is used in a low dose (100 mg twice daily) to inhibit cytochrome P450 (CYP) 3A4 and thereby increaseExpand
Principles of Signal Detection in Pharmacovigilance
A proposal is made for a standard signal management procedure at pharmacovigilance centres, including the following steps: signal delineation, literature search, preliminary inventory of data, collection of additional information, consultation with the World Health Organization Centre for International Drug Monitoring and the relevant drug companies, aggregated data assessment and a report in writing. Expand