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HIV Protease Inhibitors

Known as: Inhibitors, HIV Protease, HIV Protease Inhibitor, Protease Inhibitors, HIV 
A protease inhibitor that is designed to target the human immunodeficiency virus (HIV) protease while sparing other host cell proteases. HIV protease… Expand
National Institutes of Health

Papers overview

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Review
2010
Review
2010
HIV protease plays a crucial role in the viral life cycle and is essential for the generation of mature infectious virus… Expand
Highly Cited
2007
Highly Cited
2007
Purpose: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration… Expand
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Highly Cited
2005
Highly Cited
2005
Several human immunodeficiency virus (HIV) protease inhibitors, including atazanavir, indinavir, lopinavir, nelfinavir, ritonavir… Expand
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Highly Cited
2005
Highly Cited
2005
The HIV protease inhibitor class of antiretroviral drug causes unpredicted adverse effects by changing elements of normal… Expand
Highly Cited
2005
Highly Cited
2005
Human immunodeficiency virus (HIV) protease inhibitors (PIs) are inhibitors of CYP3A enzymes, but the mechanism is poorly defined… Expand
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Highly Cited
2000
Highly Cited
2000
  • H. Murata, Paul W. Hruz, Mike Mueckler
  • The Journal of Biological Chemistry
  • 2000
  • Corpus ID: 30356209
Retroviral protease inhibitors used as therapy for HIV-1 infection have been causally associated with serious metabolic side… Expand
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Highly Cited
2000
Highly Cited
2000
  • E. Choo, B. Leake, +4 authors R. Kim
  • Drug metabolism and disposition: the biological…
  • 2000
  • Corpus ID: 1655499
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and… Expand
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Highly Cited
1997
Highly Cited
1997
Coadministration with the human immunodeficiency virus (HIV) protease inhibitor ritonavir was investigated as a method for… Expand
Highly Cited
1994
Highly Cited
1994
Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are… Expand
Highly Cited
1994
Highly Cited
1994
A series of HIV protease inhibitors possessing a hydroxylaminepentanamide transition state isostere have been developed… Expand