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Mitoguazone

Known as: guanylhydrazone, 1,1'-[(methylethanediylidene)dinitrilo)diguanidine, mga 
A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (19)

1,4-benzoquinone guanylhydrazone thiosemicarbazoneBCOMM protocolMAMI protocolMINE regimen

Broader (3)

Antineoplastic AgentsEnzyme InhibitorsHydrazones
In BloodMethyl-gagMitoguazone DihydrochlorideNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
Apoptosis of the midline glia during Drosophila embryogenesis: a correlation with axon contact.
We have examined cell death within lineages in the midline of Drosophila embryos. Approximately 50% of cells within the anterior… 
Highly Cited
1989
Highly Cited
1989
Polyamine depletion is associated with altered chromatin structure in HeLa cells.
HeLa cells depleted of polyamines by treatment with alpha-difluoromethylornithine (DFMO), methylglyoxal bis(guanylhydrazone… 
Highly Cited
1988
Highly Cited
1988
Characterization of the inducible polyamine transporter in bovine lymphocytes.
The polyamine uptake system in bovine lymphocytes was activated by concanavalin A. The system was common to putrescine… 
Highly Cited
1984
Highly Cited
1984
Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum.
Highly Cited
1980
Highly Cited
1980
Polyamine biosynthesis enzymes in the induction and inhibition of differentiation in Friend erythroleukemia cells.
O-Ornithine decarboxylase (ODC) activity in cultures of Friend erythroleukemia cells induced to differentiate with various… 
Highly Cited
1979
Highly Cited
1979
Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.
Abstract This paper examines the relationship between inhibition of DNA replication and reduced polyamine levels in bovine… 
Highly Cited
1979
Highly Cited
1979
Suppression of the formation of polyamines and macromolecules by DL-alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes.
1. The activation of human peripheral blood lymphocytes by phytohaemagglutinin in vitro was accompanied by striking increases in… 
Highly Cited
1975
Highly Cited
1975
Regulation of ornithine decarboxylase in 3T3 cells by putrescine and spermidine: indirect evidence for translational control.
Addition of putrescine of spermidine prevents the increase in ornithine decarboxylase activity in cultures of 3T3 cells brought… 
Highly Cited
1974
Highly Cited
1974
Spermidine as a possible mediator of glucocorticoid effect on milk protein synthesis in mouse mammary epithelium in vitro.
Abstract Several lines of evidence are presented for the involvement of spermidine in milk protein synthesis during hormone… 
Highly Cited
1973
Highly Cited
1973
Effect of methylglyoxal bis(guanylhydrazone) on polyamine metabolism in normal and regenerating rat liver and rat thymus.
1. Injections of sublethal doses of methylglyoxal bis(guanylhydrazone), a potent inhibitor of putrescine-activated S… 
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