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Mitoguazone

Known as: guanylhydrazone, 1,1'-[(methylethanediylidene)dinitrilo)diguanidine, mga 
A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (19)

1,4-benzoquinone guanylhydrazone thiosemicarbazoneBCOMM protocolMAMI protocolMINE regimen

Broader (3)

Antineoplastic AgentsEnzyme InhibitorsHydrazones
In BloodMethyl-gagMitoguazone DihydrochlorideNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1984
1984
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
The uptake of exogenously administered radiolabeled polyamines by a rat prostate-derived tumor line, the Dunning R3327 MAT-Lu… 
1984
1984
Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone).
Previous results have suggested that ethylglyoxal bis(guanylhydrazone) is a more specific inhibitor of polyamine biosynthesis… 
1981
1981
Death of tumor cells in response to the use of a system of stimulated polyamine uptake from the transport of methylglyoxal bis(guanylhydrazone).
Putrescine and spermidine depletion produced by α-difluoromethylornithine, an irreversible inhibitor of omithine decarboxylase… 
1980
1980
Relation of the antiproliferative action of methylglyoxal-bis(guanylhydrazone) to the natural polyamines.
Enzymic determinations of intracellular concentrations of methylglyoxal-bis(guanylhydrazone), an anticancer drug which inhibits… 
1980
1980
Prolactin regulation of casein gene expression: possible mediators.
The role of polyamines and cyclic nucleotides as possible mediators of PRL action on casein gene expression has been studied in… 
Highly Cited
1979
Highly Cited
1979
Suppression of the formation of polyamines and macromolecules by DL-alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes.
1. The activation of human peripheral blood lymphocytes by phytohaemagglutinin in vitro was accompanied by striking increases in… 
Highly Cited
1979
Highly Cited
1979
Correlation of ultrastructural and functional damage to mitochondria of ascites L1210 cells treated in vivo with methylglyoxal-bis(guanylhydrazone) or ethidium bromide.
Mitochondria of cultured L1210 leukemia cells undergo extensive swelling and structural disruption when exposed to the anticancer… 
Highly Cited
1977
Highly Cited
1977
Inhibition of the synthesis of polyamines and DNA in activated lymphocytes by a combination of alpha-methylornithine and methylglyoxal bis(guanylhydrazone).
The cancer chemotherapeutic drug, methylglyoxal bis(guanylhydrazone), inhibits the synthesis of spermidine and spermine, but… 
1977
1977
Inhibitors of polyamine biosynthesis. 4. Effects of alpha-methyl-(+/-)-ornithine and methylglyoxal bis(guanylhydrazone) on growth and polyamine content of L1210 leukemic cells of mice.
L1210 leukemic cells of mice were incubated for a period of two generations in the presence of either alpha-methyl… 
Highly Cited
1975
Highly Cited
1975
Regulation of ornithine decarboxylase in 3T3 cells by putrescine and spermidine: indirect evidence for translational control.
Addition of putrescine of spermidine prevents the increase in ornithine decarboxylase activity in cultures of 3T3 cells brought…