Mitoguazone

Known as: guanylhydrazone, 1,1'-[(methylethanediylidene)dinitrilo)diguanidine, mga 
A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
0204019542016

Papers overview

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2005
2005
The introduction of highly active antiretroviral therapy (HAART) has significantly decreased morbidity and mortality among… (More)
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Highly Cited
2002
Highly Cited
2002
Efferent activity in the vagus nerve can prevent endotoxin-induced shock by attenuating tumor necrosis factor (TNF) synthesis… (More)
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2002
Highly Cited
2002
BACKGROUND & AIMS We investigated if inhibition of mitogen-activated protein kinases (MAPKs) was beneficial in Crohn's disease… (More)
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1998
Highly Cited
1998
Macrophages become activated by bacterial endotoxin (lipopolysaccharide) and other stimuli to release proinflammatory cytokines… (More)
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Highly Cited
1997
Highly Cited
1997
The local production of proinflammatory cytokines mediates the host response to inflammation, infection, and injury, whereas an… (More)
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1997
1997
BACKGROUND Replication of HIV-1 in human T lymphocytes requires the activation of host cellular proteins. This study identifies… (More)
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1996
1996
An overproduction of proinflammatory cytokines by activated macrophages/monocytes mediates the injurious sequelae of inflammation… (More)
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1994
1994
Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis… (More)
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Highly Cited
1981
Highly Cited
1981
The lethal effects of a 1-hr treatment with 20 antitumor drugs on proliferating and nonproliferating cultured human colon… (More)
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1978
1978
Chinese hamster ovary and rat myoblast cells resistant to the toxic action of methylglyoxal bis guanylhydrazone (MGBG), an… (More)
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