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Polyamines: mysterious modulators of cellular functions.
Polyamines were found to modulate protein synthesis at several different levels including stimulation of special kinds of protein synthesis, stimulation of the assembly of 30 S ribosomal subunits and stimulation of Ile-tRNA formation. Expand
Modulation of cellular function by polyamines.
The major focus on this review is on the role of polyamines in protein synthesis, and effects of polyamine oxidases on B to Z conversion of DNA, transcription, phosphorylation of proteins, cell cycle progression, apoptosis and ion channels. Expand
Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver.
- S. Watanabe, K. Kusama-Eguchi, H. Kobayashi, K. Igarashi
- Medicine, Biology
- The Journal of biological chemistry
- 5 November 1991
Most polyamines exist as a polyamine-RNA complex in cells under the conditions that globin synthesis is stimulated by spermine in a rabbit reticulocyte cell-free system and the amount of sPermine bound to RNA was very close to the value estimated in the cells. Expand
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.
- Y. Endo, K. Tsurugi, T. Yutsudo, Y. Takeda, T. Ogasawara, K. Igarashi
- Biology, Medicine
- European journal of biochemistry
Results indicate that both VT2 and Shiga toxin inactivate 60S ribosomal subunits by cleaving the N-glycosidic bond at A-4324 in 28S ribOSomal RNA. Expand
Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore.
- K. Kashiwagi, T. Masuko, +4 authors K. Williams
- Chemistry, Medicine
- Molecular pharmacology
- 1 March 2002
The effects of mutations in and around the membrane-spanning and pore-forming regions of NMDA receptor subunits were studied with three blockers, MK-801, memantine, and TB-3-4, using recombinant NMDA receptors expressed in Xenopus laevis oocytes. Expand
Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.
- F. Hamdan, J. Gauthier, +30 authors J. Michaud
- Biology, Medicine
- American journal of human genetics
- 11 March 2011
The importance of the glutamate receptor complexes in NSID is highlighted and the role of DNMs in this disorder is further supported, with significant excess of functional DNMs compared to neutral ones. Expand
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
It is demonstrated that immunodepletion of proteasomes from cell extracts causes almost complete loss of ATP-and antizyme-dependent degradation of ODC, suggesting that the 26S proteasome, widely viewed as specific for ubiquitin-conjugated proteins, is the main enzyme responsible for ODC degradation. Expand
A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine…
It is proposed that the tertiary structure of NR1(22-375) is similar to leucine/isoleucine /valine/valine binding protein, containing two "regulatory" domains, which are term R1 and R2. Expand
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli
- Waraporn Soksawatmaekhin, A. Kuraishi, K. Sakata, K. Kashiwagi, K. Igarashi
- Biology, Medicine
- Molecular microbiology
- 1 March 2004
The results indicate that the cadBA operon plays important roles in cellular regulation at acidic pH, and is associated with cadaverine uptake and excretion in cells. Expand
Decrease in polyamines with aging and their ingestion from food and drink.
The results suggest that maintenance of polyamine levels may play important roles in the function of the pancreas, brain and uterus in 3- to 26-week-old mice and offer useful information when it becomes necessary to ingest polyamines from food. Expand