• Publications
  • Influence
Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
  • A. Pegg
  • Biology, Medicine
  • Cancer research
  • 15 February 1988
TLDR
It should soon prove possible to block polyamine biosynthesis at every step in the pathway, and this approach will enable a full examination of the potential of this approach. Expand
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
  • A. Pegg
  • Chemistry, Medicine
  • Cancer research
  • 1 October 1990
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens that includes a number of environmentally importantExpand
Mammalian polyamine metabolism and function
  • A. Pegg
  • Biology, Medicine
  • IUBMB life
  • 1 September 2009
TLDR
This review will summarize the current state of understanding of polyamines metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism. Expand
Regulation of Ornithine Decarboxylase*
  • A. Pegg
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 26 May 2006
TLDR
Key factors that contribute to the regulation of ODC levels are described, which can occur at the levels of transcription, translation, and protein turnover. Expand
Recent advances in the biochemistry of polyamines in eukaryotes.
  • A. Pegg
  • Biology, Medicine
  • The Biochemical journal
  • 1 March 1986
Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.
TLDR
The high degree of correlation that exists between alkyltransferase activity and sensitivity to nitrosoureas indicates that elimination of this protein may reverse resistance in many cases, and two methods have been used to overcome alkylnitrosourea resistance by inactivation of alkyLtransferase. Expand
Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator.
  • A. Pegg
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 1 June 2008
TLDR
It has been suggested that SSAT may also be a useful target in diseases other than cancer, but the wide-ranging physiological and pathophysiological effects of altered SSAT expression will require very careful limitation of such strategies to the relevant cells to avoid toxic effects. Expand
Polyamine catabolism and disease.
TLDR
The dysregulation of polyamine catabolism frequently accompanies several disease states and suggests that such dysregulation may both provide useful insight into disease mechanism and provide unique druggable targets that can be exploited for therapeutic benefit. Expand
DNA binding and nucleotide flipping by the human DNA repair protein AGT
TLDR
Structural and biochemical results further support an unpredicted role for Tyr114 in nucleotide flipping through phosphate rotation and an efficient kinetic mechanism for locating alkylated bases. Expand
Repair of O(6)-alkylguanine by alkyltransferases.
  • A. Pegg
  • Medicine
  • Mutation research
  • 2000
TLDR
Alkyltransferase activity in tumors protects them from therapeutic agents such as temozolomide and BCNU, and this drug is currently in clinical trials to enhance cancer chemotherapy by these agents. Expand
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