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Mitoguazone Dihydrochloride

Known as: MGBG 2HCl, 1,1'-((Methylethanediylidene)Dinitrilo)Diguanidine Dihydrochloride, Methylglyoxal Bis(amidinohydrazone) Dihydrochloride 
The hydrochloride salt of a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine… 
National Institutes of Health

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Mitoguazone

Papers overview

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2015
2015
Synthesis of New 1,2,4-Triazole Derivatives via 1,3-Dipolar Cycloaddition Reaction of Nitrilimines with Hydrazones
A new series of 1,2,4-triazole derivatives (4a-j, 6a-j) have been synthesized by the 1,3-dipolar cycloaddition of a suitable… 
Review
2006
Review
2006
Stem cells: a regenerative pharmaceutical.
Stem cells (SC), found in both adult and fetal tissues, are self-renewing elements that can generate the various cell types in… 
2004
2004
Treatment of AIDS Related Non-Hodgkin's Lymphoma with Combination Mitoguazone Dihydrochloride and Low Dose Chop Chemotherapy: Results of a Phase II study
Purpose: To evaluate the response and side effects of combination therapy with low dose CHOP chemotherapy and mitoguazone… 
1997
1997
Hyperfixation of copper-62-PTSM in rat brain after transient global ischemia.
UNLABELLED We evaluated the regional distribution of 62Cu-pyruvaldehyde bis(N4-methylthiosemicarbazone) (62Cu-PTSM), a potential… 
1997
1997
The use of capillary electrophoresis as part of a specificity testing strategy for mitoguazone dihydrochloride HPLC methods.
Highly Cited
1993
Highly Cited
1993
Quantification of Regional Myocardial Perfusion With Generator‐Produced 62Cu‐PTSM and Positron Emission Tomography
BackgroundNoninvasive assessment of regional myocardial perfusion at rest and after stress is important for the objective… 
1992
1992
Subcellular distribution of tissue radiocopper following intravenous administration of 67Cu-labeled Cu-PTSM.
1985
1985
Response of nude mouse-grown adenocarcinomas of the human exocrine pancreas to cis-diamminedichloroplatinum(II), diammine[1,1-cyclobutanedicarboxylato(2-)-O,O'-platinum], and mitoguazone…
The effect of cisplatin, carboplatin, and mitoguazone dihydrochloride on pancreatic cancer was evaluated using pancreatic ductal… 
1968
1968
Fate of pyruvaldehyde bis(thiosemicarbazone)-35S in male and female rodents.
The excretion, distribution, and retention of pyruvaldehyde bis(thiosemicarbazone) (PTS)-35S was studied in tumor-bearing and… 
1967
1967
Sex-linked inhibition of tumors by pyruvaldehyde Bis(thiosemicarbazone).
Summary The tumor-inhibitory effect of pyruvaldehyde bis(thiosemicarbazone) was greater on 6 tumors carried in male mice and rats… 
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