Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.

@article{Seyfried1979RelationshipBI,
  title={Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.},
  author={Christine E. Seyfried and D. R. Morris},
  journal={Cancer research},
  year={1979},
  volume={39 12},
  pages={4861-7}
}
and in combination with a-MO, to block polyamine biosyn thesis. MGBG is a potent inhibitor of S-adenosylmethionine decarboxylase (2) and also is an antitumor drug with extremely toxic side effects both in experimental animals and in humans (see Ref. 1 2 for a review). MGBG can also be toxic to cells in culture and is known to introduce chromosornal breaks (for example, see Ref. 3). MGBG also induces profound alterations in mitochondriab morphology in a variety of cell types, including… CONTINUE READING

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1 Excerpt

Inhibition of the synthesis of polyamines and DNA in activated lymphocytes by a combination of amethylornithine and methylglyoxal bis ( guanylhydrazone )

  • D. R. Morris, C. M. Jorstad, C. E. Seytried
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