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Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
TLDR
Data demonstrate that signaling via the PrlR and Stat5 is critical for the proliferation and differentiation of mammary alveoli during pregnancy. Expand
Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
TLDR
It is demonstrated that GH, Prl, and EGF activate Stat5 in separate compartments, which in turn reflects their specific roles in ductal and alveolar development and differentiation. Expand
Growth control and differentiation in mammary epithelial cells.
TLDR
Complete or partial sequencing of several milk protein genes and comparative analysis have led to identification of a sequence of high homology and conservation in the 5' flanking region that is likely to be involved in the regulation of milk protein gene expression. Expand
Immunohistochemical Localization of Prothoracicotropic Hormone‐Producing Neurosecretory Cells in the Brain of Bombyx mori
TLDR
A monoclonal antibody was produced by immunizing mice with a synthetic pentadecapeptide corresponding to the amino‐terminal portion of Bombyx PTTH, demonstrating that PTTH is produced by two pairs of dorso‐lateral neurosecretory cells of the brain and transported to the corpora allata by axons running through the contralateral hemisphere of thebrain. Expand
A physiological role of epidermal growth factor in male reproductive function.
TLDR
Administration of EGF to sialoadenectomized mice restored both the sperm content of the epididymis and the number of spermatids in the testis to normal and suggested that EGF may play a role in male reproductive function by stimulating the meiotic phase of sPermatogenesis. Expand
Molecular cloning of the Bombyx mori prothoracicotropic hormone.
TLDR
The complementary DNAs encoding PTTH of the silkmoth Bombyx mori were cloned and characterized, and the complete amino acid sequence was deduced, indicating that PTTH is first synthesized as a 224-amino acid polypeptide precursor containing three proteolytic cleavage signals. Expand
Effect of salivary epidermal growth factor on wound healing of tongue in mice.
TLDR
The results suggest that salivary EGF is involved in the promotion of wound healing of the tongue in both male and female mice. Expand
Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse.
TLDR
It is proposed that the Stat3 and Stat5 lineages are derived from the duplication of a common primordial gene and that d-Stat is a part of the Stat5 lineage. Expand
Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
TLDR
The stabilization of β-catenin in prostate epithelium resulted in hyperplasias and extensive transdifferentiation into epidermal-like structures, which expressed keratins 1 and 6, filaggrin, loricrin and involucrin, which suggests a loss of prostate epithelial characteristics. Expand
Bcl-x Is Not Required for Maintenance of Follicles and Corpus Luteum in the Postnatal Mouse Ovary1
TLDR
Investigating whether the prolactin receptor (PrlR), Stat5, and Bcl-x were required for establishment and maintenance of the corpus luteum, induced pseudopregnancies in the respective gene-deletion mice found no changes in the absence of Stat5 or B cl-x. Expand
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