Microtubule Depolymerization Process

Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers and harness microtubule dynamics to… (More)

BACKGROUND Sister kinetochores must bind microtubules in a bipolar fashion to equally segregate chromosomes during mitosis. The… (More)

Hereditary spastic paraplegia (HSP) is characterized by progressive weakness and spasticity of the lower limbs, caused by the… (More)

Microtubule-depolymerizing agents are widely used to synchronize cells, screen for mitotic checkpoint defects, and treat cancer… (More)

Budding yeast Mps1p kinase has been implicated in both the duplication of microtubule-organizing centers and the spindle assembly… (More)

The ability of kinetochores to recruit microtubules, generate force, and activate the mitotic spindle checkpoint may all depend… (More)

We discovered that many proteins located in the kinetochore outer domain, but not the inner core, are depleted from kinetochores… (More)

Capillary endothelial cells can be switched between growth and differentiation by altering cell-extracellular matrix interactions… (More)

We have developed a system for studying the motions of cellular objects attached to depolymerizing microtubules in vitro. Radial… (More)

We constructed complexes between isolated chromosomes and microtubules made from purified tubulin to study the movement of… (More)