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Microtubule Depolymerization Process

Known as: Disassembly of Microtubules, microtubule disassembly, microtubule shortening 
Any microtubule process involving the removal of tubulin heterodimers from one or both ends of a microtubule.
National Institutes of Health

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7 relations
KIF2C geneKIF2C wt AlleleKinesin-Like Protein KIF2CNegative Regulation of Microtubule Depolymerization
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cytoplasmic microtubule depolymerizationmicrotubule catastrophe

Papers overview

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Highly Cited
2009
Highly Cited
2009
Motor-dependent microtubule disassembly driven by tubulin tyrosination
In cells, stable microtubules (MTs) are covalently modified by a carboxypeptidase, which removes the C-terminal Tyr residue of… 
Highly Cited
2008
Highly Cited
2008
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.
The RhoA GTPase plays a vital role in assembly of contractile actin-myosin filaments (stress fibers) and of associated focal… 
Highly Cited
2008
Highly Cited
2008
Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
Memory loss is the signature feature of Alzheimer's disease, and therapies that prevent or delay its onset are urgently needed… 
Review
2007
Review
2007
Lim kinases, regulators of actin dynamics.
  • O. Bernard
  • The international journal of biochemistry & cell…
  • 2007
  • Corpus ID: 24009594
Highly Cited
2006
Highly Cited
2006
Insights into the mechanism of microtubule stabilization by Taxol
The antitumor drug Taxol stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and cell death. Upon… 
Highly Cited
2004
Highly Cited
2004
Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity
Highly Cited
2004
Highly Cited
2004
Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles
During cell division metaphase spindles maintain constant length, whereas spindle microtubules continuously flux polewards… 
Highly Cited
1998
Highly Cited
1998
Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho.
Microtubule depolymerization has multiple consequences that include actin stress fiber and focal adhesion assembly, increased… 
Highly Cited
1991
Highly Cited
1991
Relationships between the structure of taxol analogues and their antimitotic activity.
A variety of synthetic analogues of taxol, a naturally occurring antitumor diterpene, were examined for their potency to inhibit… 
Highly Cited
1988
Highly Cited
1988
Polewards chromosome movement driven by microtubule depolymerization in vitro
We constructed complexes between isolated chromosomes and microtubules made from purified tubulin to study the movement of… 
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