Microtubule Depolymerization Process

Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers and harness microtubule dynamics to… Expand

In cells, stable microtubules (MTs) are covalently modified by a carboxypeptidase, which removes the C-terminal Tyr residue of… Expand

The RhoA GTPase plays a vital role in assembly of contractile actin-myosin filaments (stress fibers) and of associated focal… Expand

The members of the LIM kinase (LIMK) family, which include LIMK 1 and 2, are serine protein kinases involved in the regulation of… Expand

The antitumor drug Taxol stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and cell death. Upon… Expand

Alzheimer's Disease (AD) is defined histopathologically by extracellular β-amyloid (Aβ) fibrils plus intraneuronal tau filaments… Expand

Parkinson disease (PD) is characterized by the specific degeneration of dopaminergic (DA) neurons in substantia nigra and has… Expand

BACKGROUND Sister kinetochores must bind microtubules in a bipolar fashion to equally segregate chromosomes during mitosis. The… Expand

The effects of calcium (Ca) were assessed using video-enhanced differential interference contrast light microscopy on individual… Expand

We constructed complexes between isolated chromosomes and microtubules made from purified tubulin to study the movement of… Expand