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Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms
This review highlights the power of co-cultivation for increasing the chemical diversity of bacteria and fungi drawing on published studies from the marine and from the terrestrial habitat alike.
Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba.
Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus…
Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
The endophytic fungus Stemphylium globuliferum was isolated from stem tissues of the Moroccan medicinal plant Mentha pulegium, and extracts of the fungus exhibited considerable cytotoxicity when tested in vitro against L5178Y cells.
Bioactive Compounds from Marine Bacteria and Fungi
- A. Debbab, A. Aly, Wenhan Lin, P. Proksch
- Environmental Science, BiologyMicrobial biotechnology
- 19 August 2010
This review covers new biologically active natural products published recently and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.
Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin.
Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the chinese mangrove plant Rhizophora mucronata.
Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove…
Alkaloids and polyketides from Penicillium citrinum, an endophyte isolated from the Moroccan plant Ceratonia siliqua.
The endophytic fungus Penicillium citrinum was isolated from a fresh stem of the Moroccan plant Ceratonia siliqua and five new compounds, namely, citriquinochroman, showed cytotoxicity against the murine lymphoma L5178Y cell line with an IC50 value of 6.1 μM, while the other compounds were inactive (IC50 >10 μM) in this assay.
Biologically active natural products from Mongolian medicinal plants Scorzonera divaricata and Scorzonera pseudodivaricata.
The new quinic acid derivatives feruloylpodospermic acids A and B exhibited strong antioxidative activity when analyzed in the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay.
Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula.
Seven new drimane sesquiterpenoids were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula, by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS.
Fungal endophytes associated with Sonneratia (Sonneratiaceae) mangrove plants on the south coast of China
High biodiversity and tissue specificity of endophytic fungi is found, and Cytospora, Diaporthe, Fusarium, Glomerella, Mycosphaerella, Phoma, Phomopsis and Stemphylium were the dominant fungal taxa.