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Fungal endophytes: unique plant inhabitants with great promises
The chemical potential of endophytic fungi for drug discovery will be discussed with focus on the detection of pharmaceutically valuable plant constituents as products of fungal biosynthesis. Expand
Temporal variation of the microbial community associated with the mediterranean sponge Aplysina aerophoba
It is postulated that a large fraction of sponge-associated bacteria resides permanently in the Aplysina aerophoba mesohyl pointing to a highly integrated interaction between the host sponge and associated microorganisms. Expand
Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products
This overview will highlight the chemical potential of endophytic fungi with focus on the detection of pharmaceutically valuable plant constituents, e.g. paclitaxel, camptothecin and podophyllotoxin, as products of fungal biosynthesis, and new bioactive metabolites reported in recent years from fungal endophytes of terrestrial and mangrove plants. Expand
Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products
This protocol gives a detailed description of methods useful for the isolation and cultivation of fungi associated with various marine organisms for the extraction, characterization and structure elucidation of biologically active secondary metabolites produced by these marine-derived endophytic fungi. Expand
Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibitedExpand
Drugs from the seas – current status and microbiological implications
Molecular methods have successfully been applied to study the microbial diversity in marine sponges and to gain evidence for an involvement of bacteria in the biosynthesis of the bryostatins in the Bryozoan Bugula neritina. Expand
Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms
This review highlights the power of co-cultivation for increasing the chemical diversity of bacteria and fungi drawing on published studies from the marine and from the terrestrial habitat alike. Expand
Inhibition of marine biofouling by bacterial quorum sensing inhibitors
It is suggested that natural products with QS inhibitory properties can be used for controlling biofouling communities and to prevent microfOUling by one of the compounds screened in this study. Expand
Pestalotiopsis a highly creative genus: chemistry and bioactivity of secondary metabolites
Fungal endophytes are receiving increasing attention by natural product chemists due to their diverse and structurally unprecedented compounds which make them interesting candidates for drugExpand
Activated Chemical Defense in Aplysina Sponges Revisited
It is concluded that tissue damage induces a bioconversion of isoxazoline alkaloids into aeroplysinin-1 and dienone in Aplysina sponges, and this reaction is likely catalyzed by enzymes, and it may be ecologically relevant as theBioconversion products possibly protect the wounded sponge tissue from invasion of bacterial pathogens. Expand